Serum total carbon dioxide as a prognostic factor for 28-day mortality in patients with sepsis

This study was performed to investigate the association between serum total carbon dioxide (TCO2) concentration and 28-day mortality in patients with sepsis.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research

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Authors: Pampa-Saico S, Pintado V, Muriel A, Caravaca-Fontan F, Yerovi-León E, Rojo-Sanchis A, Del Rey JM, Tenorio MT, Liaño F Abstract BACKGROUND: Colistimethate sodium (CMS) treatment has increased over the last years, being acute kidney injury (AKI) its main drug-related adverse event. Therefore, this study aimed to evaluate the incidence and risk factors associated with AKI, as well as identifying the factors that determine renal function (RF) outcomes at six months after discharge. MATERIALS AND METHODS: This retrospective study included adult septic patients receiving intravenous CMS for at ...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
A 51-year old man in his fourth-line with daratumumab after two autologous cell transplantation for an IgG-kappa myeloma was admitted to the intensive care unit for septic shock with multi-organ failure. On examination, he had febrile respiratory failure with left inferior lobe pulmonary crackling. The skin was covered with diffuse painful nodular ringworm-shaped lesions surrounded by an erythematous halo without mucosal involvement Fig. 1, Panel A and B. Biology showed arterial hyperlactatemia at 9.5  mmol/l and pancytopenia.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. Further, septic shock, late-onset cardiac dysfunction, and multiorgan system failure are also described as contributors to overall mortality. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being uti...
Source: ASAIO Journal - Category: Medical Devices Tags: Management of COVID-19 Patients Source Type: research
Authors: Montrucchio G, Sales G, Scanu M, Bosso S, Brazzi L PMID: 32463213 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Biomarkers are valuable tools for the prediction of mortality in patients with sepsis. However, the use of a single biomarker to predict patient outcomes is challenging owing to the complexity and redundancy of the immune response to infections. We aimed to conduct a prospective observational analysis to investigate the prognostic value of pentraxin 3, interleukin 6, procalcitonin, and lactate combined in predicting the 28-day mortality rate in patients with sepsis or septic shock (n = 160; sepsis, 78; sepsis shock, 82). Two methods (the frequency sum of values above the cutoff, and the multivariate logistic regressio...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
In a recent study published in The Journal of Pediatrics, Scott et  al1 reported findings from an analysis that described the development and validation of a prediction model that detects septic shock in children by leveraging routine electronic health record data. The prediction model described in the authors' analysis predicts the probability of a pediatric pat ient with suspected sepsis experiencing septic shock during their medical encounter in urgent care, thereby increasing the chance of early detection and survival.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Statistics, Explained Source Type: research
Annals of the American Thoracic Society,Volume 17, Issue 6, Page 773-776, June 2020.
Source: Annals of the American Thoracic Society - Category: Respiratory Medicine Authors: Source Type: research
This study evaluated the safety and pharmacokinetics of nangibotide and its effects on clinical and pharmacodynamic parameters in septic shock patients.MethodsThis was a multicenter randomized, double-blind, two-stage study. Patients received either continuous infusion of nangibotide (0.3, 1.0, or 3.0  mg/kg/h) or placebo. Treatment began 
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19). Severe complications have been reported to occur in 33% of patients with COVID-19 and include acute respiratory distress syndrome, acute renal failure, acute respiratory injury, septic shock, and severe pneumonia. Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. The immunosuppressed status of some cancer patients (whether caused by the dis...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Review Article Source Type: research
Primer peritonitis egészséges serdülő fiúban. Orv Hetil. 2020 Jun;161(23):977-979 Authors: Farkas L, Lazáry G, Köves I, Csákváry V, Rónaky R, Nagy T Abstract Primary peritonitis is very rare in healthy children without predisposing factors. In the absence of unique factors and signs, the clinical picture does not differ from secondary peritonitis. Therefore, the diagnosis is almost always an intraoperative diagnosis. Case report: We admitted a previously healthy 15-year-old boy with symptoms of acute enteritis. Within 24 hours, he developed a...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
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