Chronic persistence of hemorrhage, microvascular obstruction and edema after myocardial infarction: Utility of Cardiac Magnetic Resonance Imaging

Publication date: Available online 6 April 2020Source: Canadian Journal of CardiologyAuthor(s): Mohammad I. Zia, Venkat Ramanan, Idan Roifman, Kim A. Connelly, Graham A. Wright, Nilesh R. Ghugre
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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In conclusion, CMR-derived hyperemic MBF could provide independent and incremental prognostic value over LVEF, LGE, and MVO in patients with STEMI.
Source: Heart and Vessels - Category: Cardiology Source Type: research
AbstractWe aimed to confirm whether gadobutrol is more useful for late gadolinium enhancement (LGE) imaging than gadopentetate dimeglumine (Gd-DTPA) at the standard dose. Patients who underwent LGE imaging to assess myocardial infarction were retrospectively enrolled: gadobutrol, 51 cases; Gd-DTPA, 49 cases. Contrast ratios of infarcted lesion to remote myocardium (CRremote) and to left ventricular blood (CRblood) were compared. Patient characteristics that might affect image contrast did not differ between groups. CRremote (median, (interquartile range)) at 10 and 15 min after administration was 0.79 (0.08) and 0.70 (0.09...
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AbstractAn increase in left ventricular volumes between baseline and follow-up imaging is the main criteria for the quantification of left ventricular remodelling (LVR) after ST-elevation myocardial infarction (STEMI), but without consensual definition. We aimed to review the criteria used for the definition of LVR based on cardiac magnetic resonance imaging (CMR) in STEMI patients. A systematic literature search was conducted using MEDLINE and the Cochrane Library from January 2010 to August 2019. Thirty-seven studies involving 4209 patients were included. Among these studies, 30 (81%) used a cut-off value for defining LV...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
The objective of this review is to summarize scientific statements on the diagnosis and management of myocardial infarction with no obstructive coronary artery disease (MINOCA); define the diagnostic role of optical coherence tomography (OCT), intravascular ultrasound (IVUS), and cardiac magnetic resonance imaging (CMR); and provide representative case examples.Recent FindingsThe majority of patients with MINOCA are evaluated by conventional coronary angiography. However, intracoronary imaging using OCT or IVUS permits more accurate understanding of the underlying pathology. These and other imaging modalities provide signi...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research
Authors: Xu Z, Chen W, Zhang R, Wang L, Chen R, Zheng J, Gao F Abstract OBJECTIVE: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling. APT102, a soluble human recombinant ecto-nucleoside triphosphate diphosphohydrolase-1, can hydrolyze extracellular nucleotides to attenuate their prothrombotic and proinflammatory effects. The purpose of this study was to temporally evaluate the therapeutic effect of APT102 on IRI in rats and to elucidate the evolution of I...
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
AbstractImmediate assessment of coronary microcirculation during treatment of ST elevation myocardial infarction (STEMI) may facilitate patient stratification for targeted treatment algorithms. Use of pressure-wire to measure the index of microcirculatory resistance (IMR) is possible but has inevitable practical restrictions. We aimed to develop and validate angiography-derived index of microcirculatory resistance (IMRangio) as a novel and pressure-wire-free index to facilitate assessment of the coronary microcirculation. 45 STEMI patients treated with primary percutaneous coronary intervention (pPCI) were enrolled. Immedi...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractReliable, closed-chest methods for creating large animal models of acute myocardial hypoperfusion are limited. We demonstrated the feasibility and efficacy of using magnetic resonance (MR) –compatible 3D-printed coronary implants for establishing swine models of myocardial hypoperfusion. We designed, manufactured, and percutaneously deployed implants in 13 swine to selectively create focal coronary stenosis. To test the efficacy of the implants to cause hypoperfusion or ischemia in the perfused territory, we evaluated regional wall motion, myocardial perfusion, and infarction using MR imaging. The overall swi...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
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PMID: 32389904 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
Abstract Acute myocardial ischemia and reperfusion injury (IRI) underly the detrimental effects of coronary heart disease on the myocardium. Despite the ongoing advances in reperfusion therapies, there remains a lack of effective therapeutic strategies for preventing IRI. Growth hormone secretagogues (GHS) have been demonstrated to improve cardiac function, attenuate inflammation and modulate the autonomic nervous system (ANS) in models of cardiovascular disease. Recently, we demonstrated a reduction in infarct size after administration of hexarelin (HEX), in a murine model of myocardial infarction. In the present...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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