Circular RNAs and their participation in stemness of cancer

AbstractCircular RNAs (circRNA) are covalently closed single-stranded RNA molecules that act as important regulators of gene expression through different mechanisms. Meanwhile, cancer stem cells (CSCs) are a small subpopulation of cells, with properties similar to normal stem cells that arise during the development of cancer and support tumor growth, induce resistance to therapy, and are responsible for metastatic spread. Since the elimination of CSCs is an important goal of cancer treatment, the circRNAs that participate in regulating gene expression and signaling pathways linked to CSCs have aroused attention in recent years, especially because it has been suggested that these molecules may function as therapeutic targets and/or clinical biomarkers. Thus, the proposal of this work is to enumerate a series of circRNAs that have been shown to play a relevant role in CSCs and explain in detail the molecular regulatory mechanisms that they establish to perform that function.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Celso Alves, Eurico Serrano, Joana Silva, Carlos Rodrigues, Susete Pinteus, Helena Gaspar, Luis M. Botana, Maria C. Alpoim, Rui Pedrosa
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/β‑catenin signaling pathway. Oncol Rep. 2020 May 27;: Authors: Ma D, Hou L, Xia H, Li H, Fan H, Jia X, Niu Z Abstract Glioblastoma is a highly malignant tumor that contains stem‑like cells known as glioma stem cells (GSCs), which lare associated with an increased risk of glioma occurrence, recurrence and poor prognosis. Circadian clock gene, period circadian clock 2 (PER2) expression has been revealed to be inhibited in various types of cancer. However, the precise role and potential mechanisms of PER2 in GSCs remai...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Targeting protein palmitoylation decreases palmitate‑induced sphere formation of human liver cancer cells. Mol Med Rep. 2020 May 22;: Authors: Chong LW, Tsai CL, Yang KC, Liao CC, Hsu YC Abstract Although non‑alcoholic fatty liver disease (NAFLD) is considered a benign disorder, hepatic steatosis has been proposed to be involved in the tumorigenesis of liver cancer. However, the underlying mechanism for carcinogenesis in fatty liver diseases remains unclear. Cancer stem cells (CSCs) have been hypothesized to serve a key role in tumorigenesis. Tumor formation begins with a subset of heterogeneous ce...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Contributors : Kiyotsugu Yoshida ; Satomi YogosawaSeries Type : Expression profiling by arrayOrganism : Homo sapiensiRFP713-lebeled iCSCL-10A cells were injected into immunodeficient mice. 5 weeks later, bone metastasized iCSCL-10A cells were extracted from bone marrow was compared with injected cell in vitro culture by microarray and pathway analysis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
meo Todaro Stassi Although improvement in early diagnosis and treatment ameliorated life expectancy of cancer patients, metastatic disease still lacks effective therapeutic approaches. Resistance to anticancer therapies stems from the refractoriness of a subpopulation of cancer cells—termed cancer stem cells (CSCs)—which is endowed with tumor initiation and metastasis formation potential. CSCs are heterogeneous and diverge by phenotypic, functional and metabolic perspectives. Intrinsic as well as extrinsic stimuli dictated by the tumor microenvironment (TME)have critical roles in determining c...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
o de Franciscis An important drawback in the management of glioblastoma (GBM) patients is the frequent relapse upon surgery and therapy. A likely explanation is that conventional therapies poorly affect a small population of stem-like cancer cells (glioblastoma stem cells, GSCs) that remain capable of repopulating the tumour mass. Indeed, the development of therapeutic strategies able to hit GSCs while reducing the tumour burden has become an important challenge to increase a patient’s survival. The signal transducer and activator of transcription-3 (STAT3) has been reported to play a pivotal role in maintain...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsThe increase in a number of genes associated with ribosome biogenesis, translation, and mTOR signaling may be important to evaluate prognosis and determine treatment approach for prostate cancer (PCa). A better understanding of the molecular pathways associated with CSCs may be promising to develop targeted therapies to prolong survival in PCa.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionOur results on the antitumor effects of ivermectin support its clinical testing.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Pack Health is participating in a pilot study with the University of California San Francisco Helen Diller Family Comprehensive Cancer Center. For Pack Health, it's the latest in a series of notable partnerships for the Birmingham-based firm. The study intends to use digital coaching to support individuals with multiple myeloma who are undergoing stem cell transplantation.  “We are excited to expand the role of digital coaching to this unique patient population for whom the transplantation…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
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