COVID-19 Diary Day 3: Facing the Prospect of Dying Alone COVID-19 Diary Day 3: Facing the Prospect of Dying Alone
After planning for staffing and patient management at his institution, oncologist Don Dizon reflects on his personal risk in managing COVID-19-positive patients.Medscape Oncology
Discussions with the FDA are ongoing to define the required data set for filing Janssen’s Ebola vaccine regimen under the FDA’s Animal Rule licensure pathway. About Janssen’s Ebola Vaccine Regimen The Janssen investigational preventive Ebola vaccine regimen (Ad26.ZEBOV, MVA-BN-Filo) utilizes a viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors are modified to safely carry the genetic code of an Ebola virus protein in order...
Publication date: Available online 27 May 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Vitor Oliveira Carvalho, Caroline Oliveira Gois
Publication date: Available online 26 May 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Allison Ramsey, Luanna Yang, Karthik Vadamalai, S. Shahzad Mustafa
WebMD Chief Medical Officer John Whyte talks with Dr Luciana Borio about the failures of the US response to the coronavirus pandemic and how much longer physical distancing will be necessary.WebMD
AbstractCoronavirus disease 2019 (COVID-19) is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and abnormal, overactivated innate immunity and “cytokine storms” have been proposed as potential pathological mechanisms for rapid COVID-19 progression. Theoretically, asthmatic patients should have increased susceptibility and severity for SARS-CoV-2 infection due to a deficient antiviral immune response and the tendency for exacerbation el icited by common respiratory viruses. However, existing studies have not shown an expected prevalence of asthmatic in...
Timely and appropriate application of methylprednisolone in severe and critical COVID-19 patients could effectively avoid invasive mechanical ventilation and reduce the mortality.
SARS-CoV-2 infection and development of COVID-19 disease presents a major healthcare challenge of global dimensions. Laboratory diagnostics of infected patients, and the assessment of immunity against the SARS-CoV-2 virus presents a major cornerstone in handling the pandemic. Currently there is an increase in demand of antibody testing and a large number of tests are already marketed or in the late stage of development. However, the interpretation of test results depends on many variables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protectivity; the diagnostic value of antibodies o...
The objective of this review is to exp lore links between biodiversity on all scales and allergic disease as a measure of immune dysregulation.
We read with attention the very recent Editorial by Navel et al1 in the latest issue of the Journal. The topic intrigued us because we are currently investigating how come Italy is cropped into 2 great coronavirus disease 2019 (COVID-19)-infected macro areas, an upstream (Northern) zone and a downstream (Central-Southern) zone, with respect to the river Po. More recent data from the Italian Ministry of Health assessed that the 7 regions in the Northern macro area account for about 79.81% of the whole severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive population.
We read with considerable interest the relevant comment of Chirumbolo and Bj ørklund1 concerning our recent Editorial.2 The authors discussed the complex link between the prevalence of coronavirus disease 2019 (COVID-19) in Italy and the geographic zones of a peninsula location, air pollution related to different climates, and allergic diseases of the respiratory tract. As explained by the authors, it is very intriguing that the Northern zone of the Italian peninsula (ie, north of the river Po) is more affected by COVID-19 than the Central-Southern zone, but it is a common observation in most of the affected countries around the world.