Mucinous adenocarcinoma of the appendix invading the urinary bladder
Publication date: Available online 7 April 2020Source: Urology Case ReportsAuthor(s): G.B. de Figueiredo, G.R. Bechara, D.G. Marquesi, R.D. Jarske, C.F. Borges
CONCLUSIONS: This Cochrane review has indicated that there are no RCTs to compare management options in this vital area, therefore trials should be undertaken as a matter of urgency. The problems with such randomised methods are standardising surgery and endotherapies in all sites, standardising histopathology in all centres, assessing which patients are fit or unfit for surgery and making sure there are relevant outcomes for the study (i.e. long-term survival (over five or more years)) and no progression of HGD. PMID: 32442322 [PubMed - as supplied by publisher]
CONCLUSIONS: INSM1 is a useful marker of neuroendocrine differentiation in gastrointestinal neuroendocrine and mixed neuroendocrine neoplasms. Compared with traditional neuroendocrine markers, INSM1 is less sensitive but more specific. PMID: 32128564 [PubMed - as supplied by publisher]
CONCLUSION Appendiceal tumors are possible findings in appendix specimens, and most patients had uncomplicated acute appendicitis. In light of findings we conclude that CT cannot be used to exclude neoplastic etiology underlying acute appendicitis. LEVEL OF EVIDENCE Diagnostic, level IV.
The Board is concerned that on December 31, 2017, a surgical pathology specimen was submitted to you, following an appendectomy with colostomy performed on Patient A. Within two weeks, you communicated a verbal preliminary report finding a likely adenocarcinoma of the appendix. Your final report was not submitted until more than six months later on July 14, 2018. The Board had your care of Patient A reviewed by an outside medical expert in pathology. This expert opined that you fell below... North Carolina Medical Board: Adenocarcinoma of Appendix
ConclusionWe reported a Tunisian case of Paneth cell colonic adenocarcinoma. The diagnosis is challenging in biopsies when only well-differentiated areas are sampled. Lysozyme immune-histochemical stain may be helpful when diagnosis difficulty arises. The beta-catenin pathway seems to be activated. More studies are needed for the etiology, pathogenesis, clinical course, prognosis and treatment of Paneth cell carcinoma.
Neuroendocrine neoplasms (NENs) of the gastrointestinal (GI) tract and pancreas are a rare and heterogeneous group of neoplasms characterized by common cellular features as well as unique site-specific traits. GI and pancreatic NENs are much rarer than the more common adenocarcinomas arising at these sites. However, the incidences of GI and pancreatic NENs have increased significantly, particularly in the stomach and common site, followed by rectum, appendix, colon, and stomach. Pancreatic NENs are also uncommon, with fewer than 1 per 100,000, accounting for 1% to 2% of all pancreatic neoplasms.
ConclusionsPeritoneal carcinomatosis of unknown primary site may be caused by an occult appendiceal adenocarcinoma. This error in diagnosis may lead to suboptimal treatment. Surgical exploration to visualize a normal appendix should occur prior to making a definitive diagnosis of peritoneal carcinomatosis of unknown primary site.
Authors: Vinck EE, Villarreal RA, Luna-Jaspe C, Cabrera LF, Peterson TF, Bernal F, Roa CL Abstract Background: The intra-operative classification of appendicitis defines postoperative treatment. The correct designation can influence patient recovery, complications and hospital costs. Recent research has shown that intra-operative classification criteria varies among surgeons, and is not always the same as the pathologist's report. Classification accuracy can lower costs by preventing unnecessary treatment or sub-optimal interventions. Methods: During a period of 4 months, N = 133 appendix specimens we...
CONCLUSION: The history of renal scleroderma crisis and the positivity of anti-topoisomerase I antibodies were associated with an increased risk of cancer in SSc patients in this monocentric study. PMID: 31255252 [PubMed - as supplied by publisher]
Endoscopy DOI: 10.1055/a-0919-4249 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Full text