The DETECT(Digital Engagement & Tracking for Early Control, & Treatment) Study

Conditions:   Influenza;   Virus Intervention:   Sponsors:   Scripps Translational Science Institute;   CareEvolution Healthcare Technology Recruiting
Source: - Category: Research Source Type: clinical trials

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One scientist says Cummings affair ‘not a recipe for public trust’ at key stage of lockdownCoronavirus – latest updatesSee all our coronavirus coverageThe government is facing increasing pressure from its scientific advisers over the decision to ease England ’s lockdown, with one warning that the Dominic Cummings affair has eroded trust in its authority.Prof Robert West, a member of the Scientific Pandemic Influenza Group on Behaviours (SPI-B) that advises the Scientific Advisory Group for Emergencies (Sage), emphasised on Saturday that about 8,000 infections, and 400 deaths, are still happening eac...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Politics UK news Science Boris Johnson Source Type: news
Bloom Influenza virus infection elicits antibodies against the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving protein neuraminidase (NA). Because HA is essential for viral entry, antibodies targeting HA often potently neutralize the virus in single-cycle infection assays. However, antibodies against NA are not potently neutralizing in such assays, since NA is dispensable for single-cycle infection. Here we show that a modified influenza virus that depends on NA for receptor binding is much more sensitive than a virus with receptor-binding HA to neutralization by some anti-NA antibodies. Specif...
Source: Viruses - Category: Virology Authors: Tags: Brief Report Source Type: research
Conclusions: An onsite vaccination strategy failed in providing a remarkable increase in VCR in 2019, but it is important to point out that the campaign was influenced by several logistic problems.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
The global pandemic of SARS-CoV-2, the cause of Coronavirus disease 2019 (COVID-19), has been associated with worse outcomes in several patient populations, including the elderly and those with chronic comorbidities. Data from previous pandemics and seasonal influenza suggest that pregnant women may be at increased risk for infection-associated morbidity and mortality. Physiological changes in normal pregnancy and metabolic and vascular changes of high-risk pregnancies may affect pathogenesis or exacerbate the clinical presentation of COVID-19.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Review Source Type: research
Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. Their simple modular structure and single open reading frame format are highly amenable to gene therapy-mediated delivery. We have previously described R1a-B6, an alpaca-derived single domain antibody (nanobody), that is capable of potent cross-subtype neutralization in vitro of H1N1, H5N1, H2N2, and H9N2 influenza viruses, through binding to a highly conserved epitope in the influenza hemagglutinin stem region. To evaluate the potential of R1a-B6 for immunoprophylaxis, we have re...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: There is a need to improve respiratory infectious disease procedures in our study hospitals, especially in outpatient and emergency departments. PMID: 32459978 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
John Barry, an expert on the 1918 influenza pandemic, spoke with Major Garrett for this week's episode of "The Takeout" podcast.
Source: Health News: - Category: Consumer Health News Source Type: news
(Northwestern University) As if the COVID-19 pandemic isn't scary enough, the flu season is not far away. How severe will the flu season be as it converges with the COVID-19 outbreak? What can we do to prepare? Dr. Benjamin Singer, a Northwestern Medicine pulmonologist who treats COVID-19 patients in the intensive care unit, outlines the best defense against influenza, which also may protect against coronavirus.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The seasonal influenza epidemic is an important public health issue worldwide. Early predictive identification of patients with potentially worse outcome is important in the emergency department (ED). Similarl...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
InspectIR Systems has launched a clinical trial focused on using a mobile device for the detection of the novel coronavirus (COVID-19). The Frisco, TX-based company began the trial on Wednesday and said it will test the InspectIR portable breathalyzer. "As most of us have experienced, the world has changed due to the coronavirus pandemic. We challenged our development teams with a simple question: 'Can we help?' We quickly realized our devices could identify COVID-19 in the breath and help with the unique circumstances facing the U.S. and the world right now," InspectIR CEO Tim Wing, said in a release. "It p...
Source: MDDI - Category: Medical Devices Authors: Tags: COVID-19 IVD Source Type: news
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