Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

Conditions:   Prostate Cancer;   Refractory Cancer;   Castration Resistant Prostatic Cancer Intervention:   Drug: Omeprazole 80 mg twice daily Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Ground-breaking research, together with greater awareness - highlighted by the Daily Mail's End The Needless Prostate Deaths campaign - is changing the outlook for men with the condition.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Shares of Myovant Sciences Ltd. soared as much as 55% Monday after the company this weekend unloaded fresh data around a drug for prostate cancer and said this morning that it is asking regulators to approve the same drug's use to treat women with uterine fibroids. The 214-employee company (NYSE: MYOV), with its main offices in Brisbane, said a late-stage prostate cancer study of its drug relugolix expanded on earlier findings, finding its once-a-day pill has a lower risk of heart problems compared…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Investigational agent relugolix was non-inferior to leuprolide but also significantly cut the risk of major adverse cardiovascular events.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Abstract Polymorphic variants in the PTEN (rs2735343), PI3K (rs2699887), AKT1 (rs2494750), AR (rs17302090), and AMACR (rs3195676) genes were evaluated as possible molecular markers of susceptibility, prognosis, and progression of prostate cancer (PCa), in a case-control study. Samples consisted of 277 patients with PCa and 277 controls from Londrina, PR, Brazil. SNPs were analyzed by real-time PCR. A family history of cancer, including PCa, as well as level of schooling were risk factors for PCa. The data were obtained via logistic regression, using odds ratios with a CI 95%. The genotypes of AKT1 and AKT1+AR demonstrated ...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
ABSTRACT Objective To assess the association between prostate volume index (PVI), and prostatic chronic inflammation (PCI) as predictors of prostate cancer (PCA). PVI is the ratio between the central transition zone volume (CTZV) and the peripheral zone volume (PZV). Materials and methods Parameters evaluated included age, prostate specific antigen (PSA), total prostate volume (TPV), PSA density (PSAD), digital rectal exam (DRE), PVI, PCI and number of positive cores (NPC). All patients underwent baseline 14-core, trans-perineal random biopsies. Associations of parameters with the NPC were investigated by univariate and mu...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
ABSTRACT Objectives Fusion prostate biopsy (FPB) has recently emerged as a popular and successful biopsy technique on diagnosis of prostate cancer. The aim of this study was to compare the pain levels in TRUS-guided standard 12-core prostate biopsy (SPB) and MpMRI-guided FPB. Materials and Methods Patients detected with a PI-RADS (Prostate Imaging Reporting and Data System) ≥ 3 lesion on MpMRI underwent MpMRI-guided FPB (Group I) and the patients who had no suspected lesions or had a PI-RADS
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
ABSTRACT Objectives Fusion prostate biopsy (FPB) has recently emerged as a popular and successful biopsy technique on diagnosis of prostate cancer. The aim of this study was to compare the pain levels in TRUS-guided standard 12-core prostate biopsy (SPB) and MpMRI-guided FPB. Materials and Methods Patients detected with a PI-RADS (Prostate Imaging Reporting and Data System) ≥ 3 lesion on MpMRI underwent MpMRI-guided FPB (Group I) and the patients who had no suspected lesions or had a PI-RADS
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusions 223Ra therapy require an adequate selection of patients to obtain the greatest clinical benefit. Low basal Hb, hight basal ALP, bone marrow involvement and an altered ECOG were the main factors that decreased OS in our patients. 223Ra should be considered relatively early in the course of treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Conclusions 223Ra therapy require an adequate selection of patients to obtain the greatest clinical benefit. Low basal Hb, hight basal ALP, bone marrow involvement and an altered ECOG were the main factors that decreased OS in our patients. 223Ra should be considered relatively early in the course of treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
This study investigated the expression of miRNA-182 and miRNA-187 in prostate cancer patients and established a correlation between miRNA expression and staging of prostate cancer. Materials and Methods This prospective observational study involved patients undergoing transrectal ultrasound-guided biopsy for suspicion of prostate cancer. Pre-biopsy urine samples and prostatic core tissue samples of the patients were preserved and the miRNA-182 and miRNA-187 were studied. Results Sixty-three patients were included in this study, thirty-three patients were diagnosed with prostate cancer and thirty patients having benign hist...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
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