Isatis tinctoria L.-derived Petroleum Ether Extract Mediates Anti-inflammatory Effects via Inhibition of Interleukin-6, Interleukin-33 and Mast Cell Degranulation.

In conclusion, novel woad extracts were developed and shown to have anti-inflammatory properties in a contact hypersensitivity animal model and human keratinocytes. The production of such extracts and further characterization of their specific properties will enable determination of their potential dermatological effects in the treatment of inflamed and irritated skin. PMID: 32250439 [PubMed - as supplied by publisher]
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Authors: Mu Z, Zhang J Abstract Atopic Dermatitis (AD) is a common inflammatory disease with a genetic background. The prevalence of AD has been increasing in many countries. AD patients often have manifestations of pruritus, generalized skin dryness, and eczematous lesions. The pathogenesis of AD is complicated. The impaired skin barrier and immune imbalance play significant roles in the development of AD. Environmental factors such as allergens and pollutants are associated with the increasing prevalence. Many genetic and environmental factors induce a skin barrier deficiency, and this can lead to immune imbalanc...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
This study will investigate whether the addition of a reminder app to standard care can reduce dermatitis and oral mucositis rates during radiotherapy in these patients.MethodsThis randomized trial compares standard care supported by a reminder app (Arm A) to standard care alone (Arm B) with respect to grade  ≥ 2 radiation dermatitis and oral mucositis at 60 Gy of radiotherapy, the minimum planned dose for patients receiving definitive or adjuvant radiotherapy for locally advanced head- and-neck cancer. Moreover, radiation-induced dermatitis and oral mucositis grade ≥ 3 at 60 Gy and both g...
Source: Trials - Category: Research Source Type: clinical trials
AbstractThe diagnosis of mange is problematic in the absence of mites in skin scrapings because many skin diseases present similar gross features as mange. The study evaluated the stepwise procedure for herd diagnosis of mange in the West African Dwarf (WAD) and Red Sokoto (RS) goats with greater specificity and sensitivity. Twenty-seven WAD goats (n = 27) and forty RS goats (n = 40) goats with mange-like skin lesions (alopecia, scabs, crusts, and scratch injuries) out of a total herd population of 114 WAD goats and 317 RS goats respectively in Nsukka, Eastern Nigeria, were examined by directed ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
Authors: Fargnoli MC, Esposito M, Ferrucci S, Girolomoni G, Offidani A, Patrizi A, Peris K, Costanzo A, Malara G, Pellacani G, Romanelli M, Amerio P, Cristaudo A, Flori ML, Motolese A, Betto P, Patruno C, Pigatto P, Peccianti C, Stinco G, Zalaudek I, Bianchi L, Boccaletti V, Cannavo SP, Cusano F, Lembo S, Mozzillo R, Gallo R, Potenza C, Rongioletti F, Tiberio R, Grieco T, Micali G, Persechino S, Pettinato M, Pucci S, Stingeni L, Caruso C, Argenziano G, Dupilumab Italian National Access Program (Dup-INAP Group) Abstract The long-term efficacy and safety of dupilumab has been demonstrated in clinical trials and only ...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Calzavara-Pinton P, Belloni Fortina A, Bonamonte D, Marseglia GL, Miraglia Del Giudice M, Musarra A, Nettis E, Neri I, Patruno C, Stingeni L, Peris K, RADAR Group Abstract Atopic dermatitis (AD) is a chronic inflammatory disease with increasing global incidence, which has a multifactorial pathogenesis and a variable expressivity. Clinical features of AD are different in adults compared to children, but it is well recognized the substantial impact of the disease on patients' quality of life at any age. Indeed, little is known about AD in adolescence, a period of life generally associated with high psycholog...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Current valid instruments that measure the signs of AD in clinical trials may not be suitable for clinical practice due to their complexity. The product of a clinician-derived 5-point signs global assessment and body surface area (SGAxBSA) may represent a simple approach to quickly assess the severity of signs in patients with AD in clinical practice.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
CONCLUSION: CyA and Duplimab, that were effective in AD with intractable prurigo nodularis, are expected to become indications for AD children. PMID: 32435023 [PubMed - in process]
Source: Allergology International - Category: Allergy & Immunology Tags: Arerugi Source Type: research
CONCLUSION: These results suggest the long-term usefulness of rupatadine for pruritus in AD. PMID: 32435018 [PubMed - in process]
Source: Allergology International - Category: Allergy & Immunology Tags: Arerugi Source Type: research
Conclusion: Due to individual-dependent characteristics as well as different severity of atopic dermatitis, the indication of one best preparation for patients is problematic. However, we believe that our study is one of the milestones on the way to the best emollient individually tailored to the patient's skin. PMID: 32431184 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
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Source: eMedicineHealth.com - Category: General Medicine Source Type: news
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