Prevalence and Outcomes of Pediatric In-Hospital Cardiac Arrest Associated With Pulmonary Hypertension*

The objective of this study was to determine the prevalence of pulmonary hypertension among children with in-hospital cardiac arrest and its impact on outcomes. Design: Retrospective single-center cohort study. Setting: PICU of a quaternary care, academic children’s hospital. Patients: Children (
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Articles Source Type: research

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Despite advances in left ventricular assist device (LVAD) technology, right ventricular failure (RVF) continues to be a complication after implantation. Most patients undergoing LVAD implantation have underlying right ventricular (RV) dysfunction (either as a result of prolonged LV failure or systemic disorders) that becomes decompensated post-implantation. Additional insults include intra-operative factors or a sudden increase in preload in the setting of increased cardiac output. The current literature estimates post-LVAD RVF from 3.9% to 53% using a diverse set of definitions. A few of the risk factors that have been id...
Source: ASAIO Journal - Category: Medical Devices Tags: Review Article Source Type: research
Discussions with the FDA are ongoing to define the required data set for filing Janssen’s Ebola vaccine regimen under the FDA’s Animal Rule licensure pathway. About Janssen’s Ebola Vaccine Regimen The Janssen investigational preventive Ebola vaccine regimen (Ad26.ZEBOV, MVA-BN-Filo) utilizes a viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors are modified to safely carry the genetic code of an Ebola virus protein in order...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Annals of the American Thoracic Society,Volume 17, Issue 6, Page 779-783, June 2020.
Source: Annals of the American Thoracic Society - Category: Respiratory Medicine Authors: Source Type: research
The mainstream (&the sidestream) medical media have already named one culprit ie hypertension (HT) as a significant comorbid entity in the current Corona pandemic. But, If we ask one direct question, how Corona and HT are linked ? , the answer is not forthcoming fluently. . Some of the thought process about the Issue. 1. Does Coronavirus relish high blood pressure on its journey to attack lungs ? Funny question you may think. The virus primarily lives and tracts through the respiratory tract to reach lungs. Viral load in bloodstream is nil or  miniscule till late stages. BP is nothing to do with what is ...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized what is the link between hypertension and corona outcome Source Type: blogs
Authors: Bellan M, Dimagli A, Piccinino C, Giubertoni A, Ianniello A, Grimoldi F, Sguazzotti M, Nerviani A, Barini M, Carriero A, Smirne C, Burlone ME, Rigamonti C, Minisini R, Salmi L, Barbaglia MN, Castello LM, Sola D, Marino P, Avanzi GC, Pirisi M, Sainaghi PP Abstract Background: Few biomarkers are available for early identification of pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) in systemic sclerosis (SS) and scleroderma spectrum disorders (SSD). Aims: To evaluate Gas6, sAxl, and sMer as biomarkers for cardiopulmonary complications of SS and SSD. Methods: In a cross-section...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Conditions:   Pulmonary Hypertension;   Infant, Premature Intervention:   Sponsors:   Mount Sinai Hospital, Canada;   Sunnybrook Health Sciences Centre;   Liverpool Women's NHS Foundation Trust;   The Rotunda Hospital;   University of Iowa Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Pulmonary capillary haemangiomatosis (PCH) is a rare and incompletely understood histopathological finding characterised by abnormal capillary proliferation within the alveolar interstitium, which has long been noted to share many overlapping features with pulmonary veno-occlusive disease (PVOD). But are PCH and PVOD distinct entities that occur in isolation, or are they closely intertwined manifestations along a spectrum of the same disease? The classic clinical features of both PCH and PVOD include signs and symptoms related to pulmonary hypertension, hypoxaemia, markedly impaired diffusion capacity of the lung and abnor...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Pulmonary vascular disease Ultra-rare lung disease Source Type: research
Publication date: Available online 25 May 2020Source: Respiratory Physiology &NeurobiologyAuthor(s): J. Catella, F. Costes, JB Gaultier, I. Court Fortune, C. Tulane, E De Magalhaes, S Accassat, S Chomette-Ballereau, C. Chapelle, L. Bertoletti
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
ConclusionEven though CIH did not cause abnormal pulmonary function or PH, early lung injury was detected at the molecular level in rats exposed to CIH. Treatment with Ad ameliorated the pulmonary injury by activating the SIRT3/SOD2 pathway, reducing ROS generation, and inhibiting ROS-associated lung cell apoptosis.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
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