Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects

In this study, we investigated the effect of ethionine on NTDs as well as the underlying mechanism involved in this process. Following the establishment of NTDs model using ethionine-induced C57BL/6 mice, ethionine was intraperitoneally injected at a dose of 500 mg/kg in E7.5. Our study revealed that ethionine has induced mitochondrial apoptosis in NTDs by reducing mitochondrial autophagy both in vivo and in vitro. These results provided a possible molecular mechanism for redox regulation of autophagic process.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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The objective of the present study was to determine the structure of the movement pattern performed during a wheelchair fencing lunge that is executed in response to visual and sensory stimuli. In addition, a comparison was made between fencers in the categories A and B of disability. In addition, the analysis involved the correlation between the duration of the sensorimotor response and the value of the bioelectric signal recorded in selected muscles. Seven Paralympic team athletes specializing in wheelchair fencing (3 in category A and 4 in category B) participated in the research. The fencers perform at international le...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: Low-frequency rTMS is well tolerated but not effective in treating chronic tinnitus based on the current analysis of pooled data. Further studies with modified and uniform protocols are required to investigate the potential benefit of rTMS in chronic tinnitus. PMID: 32461976 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract To evaluate the clinical significance of spinal decompression and fusion for lumbar spinal stenosis in old patients under Roussouly classification, 160 old patients (>60 year old) with lumbar spinal stenosis underwent spinal decompression, and fusion were retrospectively studied. According to Roussouly classification, patients were divided into 4 groups, in which Roussouly types I, II, and IV were the nonstandard group and Roussouly type III was the standard group. Visual analog scale (waist, leg) and Oswestry disability index (ODI) scores were recorded before operation and at the final follow-up. All ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 29 May 2020Source: AlterAuthor(s): Rosa Bellacicco, Marisa Pavone
Source: ALTER - European Journal of Disability Research - Category: Disability Source Type: research
Publication date: September 2020Source: Research in Developmental Disabilities, Volume 104Author(s): K. Payne, K.L. Maras, A.J. Russell, M.J. Brosnan, R. Mills
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: September 2020Source: Research in Developmental Disabilities, Volume 104Author(s): Geraldine Leader, Maeve Murray, Páraic S. O’Súilleabháin, Leanne Maher, Katie Naughton, Sophia Arndt, Keeley White, Ivan Traina, Arlene Mannion
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: September 2020Source: Research in Developmental Disabilities, Volume 104Author(s): Ana M. Jijon, Hayley C. Leonard
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: August 2020Source: Research in Developmental Disabilities, Volume 103Author(s): Saeed S. Alqahtani
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Authors: Rui T, Li Q, Song S, Gao Y, Luo C Abstract Traumatic brain injury (TBI) is one of the most significant health care problems worldwide, causing disability and death especially among young individuals. Although a large range of agents and therapies have been proved beneficial to lesions post-TBI to some extent, effective treatments have not been translated to the clinic. As a newly discovered form of iron-dependent regulated cell death, ferroptosis has been implicated in TBI. In this review, we update the current state of knowledge related to second injuries post-TBI, including ferroptosis, oxidative stress,...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Whether the plan was always to allow the disease to spread uncontrolled through UK population or not, the UK's approach was distinctly out-of-sync with the rest of Europe
Source: Disabled World - Category: Disability Tags: European Disability News Source Type: news
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