Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease
: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD).
Early prediction of postoperative recurrence (POR) remains a major concern in Crohn's disease (CD).
We present the case of a 32-year-old (G2P0) that presented at 23 + 5 weeks` gestation with pruritus and a maculo-popular rash on all extremities and abdomen with worsening symptoms at night for 5 days before advocating medical assistance. The patient had Crohn`s disease, diagnosed at age 17, treated with 125 mg azathioprine daily, in remission a year and a half preceding pregnancy. She was otherwise healthy, with no known allergies or liver diseases. The patient received anti-histamines and various ointments for her symptoms based on dermatologist consults.
Chronic intestinal failure (IF) is a condition characterized by impairment of intestinal function below the minimum necessary for growth or even survival. This often causes the necessity to start a parenteral nutrition (PN), not without further serious related complications and risk factors. IF is mainly due to Short Bowel Syndrome (SBS) and the most common cause of SBS in adults is Crohn's disease (CD), which far exceeds 60% of the prevalence .
A 66-year-old woman with Crohn's disease received adalimumab therapy for 3 years. She developed some erythematous induration throughout her lower legs (Fig. 1). The nodules became tender and spread to the hands and elbows within 3 months (Fig. 2). Skin biopsy revealed chronic dermatitis with marked necrotizing panniculitis (Fig. 3). Acid-fast staining was positive (Fig. 4). External consultation suggested Mycobacterium haemophilum infection; thus, adalimumab therapy was ceased and combination therapy with clarithromycin, ciprofloxacin, and ethambutol was commenced.
Conclusions: Due to short follow-up time in small studies, with selection bias due to exclusion of former or prevalent malignancy in an older population, no conclusions can be drawn concerning the true association between MC and malignancy. Rheumatic diseases seem to be associated with MC. PMID: 32182146 [PubMed - as supplied by publisher]
Enhanced Recovery After Surgery (ERAS) offers many benefits for patients with colorectal cancer. However, its application to patients with Crohn ’s disease (CD) is questioned.
In recent years, despite the persistence of heterogeneous definitions, mucosal healing has become a relevant goal in the treatment of patients with inflammatory bowel disease (IBD) . In addition, in ulcerative colitis (UC), histological healing has demonstrated a potential prognostic value, overcoming the macroscopic endoscopic exclusive evaluation , and allowing that histological improvement could be suggested as a relevant end-point for clinical trials by European and American regulatory agencies.
Perianal fistulizing Crohn ’s disease (PFCD) is a common, disabling and aggressive phenotype that negatively impacts on the quality of life of affected patients. Its successful treatment is still a struggle for both physicians and patients. Significant advances in the management of this condition have occurred in the last t wo decades holding promise for a better future. This culminated into the concept of a collaborative multidisciplinary approach using the latest medical therapies combined with modern surgical and endoscopic techniques.
Diagnosis of the inflammatory bowel diseases ulcerative colitis (UC) and Crohn ’s disease (CD) relies mainly on the histopathological examination of endoscopic biopsies of the gastrointestinal tract. To facilitate the accurate diagnosis of these two conditions, this paper addresses key issues on the: (A) gastrointestinal biopsy procedure, (B) histomorphological characteristi cs of UC and CD, and (C) diagnosis of dysplasia. The 13 statements presented here represent the consensus of two groups of Italian pathologists (IG-IBD and GIPAD).
When ultrasonography was first introduced in clinical practice, its use was characterized by three dogmas: air was an insuperable limitation; the bowel was impenetrable; and the results were operator dependent. Indications that air was useful in the ultrasonographic evaluation of the gastrointestinal tract came in the early 1980s , but the first dogma was only rebutted years later when air was shown to not be an obstacle to ultrasonographic imaging of the lungs . The second dogma was first challenged by a 1979 case series  in Crohn ’s disease.