Effects of Metformin and Sitagliptin Monotherapy on Expression of Intestinal and Renal Sweet Taste Receptors and Glucose Transporters in a Rat Model of Type 2 Diabetes

In conclusion,
metformin and sitagliptin exerted different effects on expression of STRs and
glucose transporters in the gut and kidney. STRs, downstream molecules, and
glucose transporters in distal small intestinal were sensitively increased in
response to sitagliptin than metformin treatment. Renal glucose transporters
were downregulated after metformin and sitagliptin treatment. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Hormone and Metabolic Research - April 5, 2020 Category: Endocrinology Authors: Zhang, Minchun Feng, Rilu Yue, Jiang Qian, Cheng Yang, Mei Liu, Wei Rayner, Christopher K. Ma, Jing Tags: Endocrine Research Source Type: research