Early Pregnancy Prediction of Gestational Diabetes Mellitus Risk Using Prenatal Screening Biomarkers in Nulliparous Women

Gestational diabetes mellitus (GDM) is a common complication of pregnancy associated with significant maternal and neonatal morbidities, including increased risk of pre-eclampsia, macrosomia, and subsequent type 2 diabetes.[1] In most developed countries, universal glucose testing is performed at 24-28 weeks ’ gestation to identify women with overt glucose intolerance.[2] Ideally, women at high risk of developing GDM would be identified earlier in pregnancy to facilitate preventive intervention, enhance antenatal care, and improve clinical outcomes through reduced maternal and fetal exposure to metabo lic alterations and potential epigenetic malprogramming.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research

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CONCLUSIONS: Preeclampsia as well as early-onset and late-onset PE all represent risk factors for adverse cardiovascular events later in life. Early-onset PE is associated with a higher burden of cardiovascular mortality and morbidity compared to late-onset PE. This article is protected by copyright. All rights reserved. PMID: 32484256 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
CONCLUSIONS: Two new studies (406 women) have been incorporated to one of the comparisons for this update. Although the evidence suggests that CGM in comparison to intermittent glucose monitoring may reduce hypertensive disorders of pregnancy, this did not translate into a clear reduction for pre-eclampsia, and so this result should be viewed with caution. No differences were observed for other primary outcomes for this comparison. The evidence base for the effectiveness of other monitoring techniques analysed in the other five comparisons is weak and based on mainly single studies with very low-quality evidence. Additiona...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Publication date: Available online 13 December 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Mohammed Bashir, Zeinab Dabbous, Khaled Baagar, Fadi Elkhatib, Amin Ibrahim, Sanam-Alhouda Brich, Manar E. Abdel-Rahman, Justin C. Konje, Abdul-Badie Abou-SamraAbstractObjectivesTo study the pregnancy outcomes in women with type 2 diabetes mellitus (T2DM) and to relate these to maternal risk factors.MethodsWe conducted a retrospective study of 419 women with T2DM (index group)- who attended our diabetes in pregnancy clinic at the Hamad Women’s Hospital, Doha, between March 2015 ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Diabetes mellitus is common and complicates 2 –5% of pregnancies in the UK, with an increasing prevalence of pre-existing diabetes mellitus in pregnancy. Hyperglycaemia directly correlates with adverse maternal and fetal outcomes, including congenital anomaly, miscarriage, pre-eclampsia, pre-term delivery, macrosomia, stillbirth and neonatal hypoglycaemia. Optimal glycaemic control before conception and during the antenatal period is paramount to reduce these risks. Pre-pregnancy preparation should focus on glycaemic control, medication review and end-organ disease assessment.
Source: Medicine - Category: Internal Medicine Authors: Tags: Medicine and other specialties Source Type: research
CONCLUSION: The audit demonstrated outcomes similar to those in the developed world, with major congenital malformations, unexplained stillbirths and PET accounting for the majority of perinatal deaths. Stricter control with the aim of achieving lower or normal HbA1c levels before conception may be the only intervention that could bring about change. PMID: 30182903 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
CONCLUSIONS: Currently there is insufficient high-quality evidence about the effects on health outcomes of relevance for women with GDM and their babies for many of the comparisons in this overview comparing treatment interventions for women with GDM. Lifestyle changes (including as a minimum healthy eating, physical activity and self-monitoring of blood sugar levels) was the only intervention that showed possible health improvements for women and their babies. Lifestyle interventions may result in fewer babies being large. Conversely, in terms of harms, lifestyle interventions may also increase the number of inductions. T...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionsIn this large population-based cohort of women in Alberta, GDM was not associated with an increased risk for developing new-onset mental illness during pregnancy or postpartum.RésuméObjectifsExaminer la relation entre le diabète sucré gestationnel (DSG) et le développement de la maladie mentale (troubles affectifs et anxieux) au cours de la grossesse et dans l'année qui suit l'accouchement.MéthodesNous avons relié les bases de données cliniques et administratives pour repérer les diagnostics de DSG et de maladie mentale chez les mères q...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
CONCLUSIONS: There is insufficient evidence to support the use of metformin for women with obesity in pregnancy for improving maternal and infant outcomes. Metformin was, however, associated with increased risk of adverse effects, particularly diarrhoea. The quality of the evidence in this review varied from high to low, with downgrading decisions based on study limitations and inconsistency.There were only a small number of studies included in this review. Furthermore, none of the included studies included women categorised as 'overweight' and no trials looked at metformin in combination with another treatment.Future rese...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSION: To assist Chinese women with Gestational diabetes to better self-manage their condition, there is a need for clinicians to: (1) provide more effective diabetes education to ensure clear understanding of self-management principles; (2) actively elicit and respond to women's confusion and concerns; (3) provide women with adequate practical support; and (4) develop greater cultural awareness. PMID: 29693546 [PubMed - as supplied by publisher]
Source: Women Birth - Category: Midwifery Authors: Tags: Women Birth Source Type: research
Gestational diabetes mellitus is one of the most common complications of pregnancy. Women with Gestational diabetes are at increased risk of serious health outcomes, such as pre-eclampsia, obstructed labor, and the development of Type 2 diabetes later in life. Chinese migrants, the third largest cultural group in Australia, are more likely to develop Gestational diabetes than Australian-born women. However, to date, Gestational diabetes self-management has not been investigated in this population.
Source: Women and Birth - Category: Midwifery Authors: Tags: Original Research – Qualitative Source Type: research
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