Recent progresses and perspectives in autoimmune bullous diseases

Autoimmune bullous diseases (AIBDs) are prototypical organ-specific autoimmune diseases of the skin and mucous membranes.1,2 In 1953, Lever divided AIBDs into the 2 groups, pemphigus and pemphigoid diseases, depending on the location of the lesions. The major autoantigens in pemphigus diseases are keratinocyte cell surface adhesion molecules at desmosomes, and those of pemphigoid diseases are components of the epidermal basement membrane zone (BMZ) (Fig 1). Such autoantigens are depicted in Fig 1.

Source: Journal of Allergy and Clinical Immunology - March 31, 2020 Category: Allergy & Immunology Authors: Christian D. Sadik, Enno Schmidt, Detlef Zillikens, Takashi Hashimoto Tags: Paradigms and perspectives Source Type: research