ASAP Osteotropic Radiolabeled Nanophotosensitizer for Imaging and Treating Multiple Myeloma
ACS NanoDOI: 10.1021/acsnano.9b09618
Conditions: Recurrent Aggressive Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent High Grade B-Cell Lymphoma; Recurrent Malignant Neoplasm; Recurrent Plasma Cell Myeloma; Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma; Refractory Aggressive Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory High Grade B-Cell Lymphoma; Refractory Malignant Neopla...
Blood Cancer Journal, Published online: 01 June 2020; doi:10.1038/s41408-020-0331-4Blockade of VLA4 sensitizes leukemic and myeloma tumor cells to CD3 redirection in the bone marrow microenvironment
A 51-year old man in his fourth-line with daratumumab after two autologous cell transplantation for an IgG-kappa myeloma was admitted to the intensive care unit for septic shock with multi-organ failure. On examination, he had febrile respiratory failure with left inferior lobe pulmonary crackling. The skin was covered with diffuse painful nodular ringworm-shaped lesions surrounded by an erythematous halo without mucosal involvement Fig. 1, Panel A and B. Biology showed arterial hyperlactatemia at 9.5 mmol/l and pancytopenia.
Publication date: Available online 30 April 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Alessandra Malato, Elena Rossi, Mario Tiribelli, Francesco Mendicino, Novella Pugliese
Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1. Mol Med Rep. 2020 May 27;: Authors: Zhou F, Du C, Xu D, Lu J, Zhou L, Wu C, Wu B, Huang J Abstract Lung cancer is a devastating cancer with high morbidity and mortality. Ubiquitin‑specific protease (USP) is a type of deubiquitinating enzyme (DUB) that has been implicated in numerous cancers, including colorectal, myeloma and breast. In the present study, the expression of USP51 was determined in the lung cancer cell line A549 and cisplatin (a...
Authors: Pablo A, Breaud AR, Clarke W Abstract Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spec...
Teclistamab appeared to be a safe and efficacious treatment for patients with relapsed/refractory multiple myeloma, according to a phase I study presented at the ASCO Virtual Scientific Program.
Publication date: Available online 29 May 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Alexander Coltoff, Ruben Mesa, Jason Gotlib, Jessica Shulman, Raajit K. Rampal, Olivia Siwoski, Abdulraheem Yacoub, Alison Moliterno, Anna Yang, Evan Braunstein, Aaron T. Gerds, Gabriela S. Hobbs, Elliott F. Winton, Swati Goel, Martha Wadleigh, Douglas Tremblay, Erin Moshier, John Mascarenhas
Publication date: Available online 29 May 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Stefania Crisci, Elvira Pota, Giancarla Iaccarino, Irene Postiglione, Concetta Meo, Sara Mele, Rosaria De Filippi, Antonio Pinto
Publication date: Available online 29 May 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Nitya Nathwani, Joycelynne Palmer, Timothy W. Synold, Behrouz Salehian, Michael Rosenzweig, James F. Sanchez, Samantha N. Hammond, Kehinde Adekola, Valeria Tomarchio, Arnab Chowdhury, Chatchada Karanes, Myo Htut, Firoozeh Sahebi, Tanya Siddiqi, Amrita Krishnan, Stephen J. Forman, Steven T. Rosen