Sensitive, Selective Monitoring of DNA Damage-Induced Intracellular p21 Protein and Unraveling the Role of p21 Protein in DNA Repair and Cell Apoptosis by Surface Plasmon Resonance
Analyst, 2020, Accepted Manuscript DOI: 10.1039/C9AN02464F, PaperYuhan He, Zixiao Wang, Yuqing Hu, Xinyao Yi, Ling Wu, Zhong Cao, Jianxiu Wang The cyclin-dependent kinase inhibitor p21 protein is a critical regulator that mediates various biological activities, such as cell cycle progression, apoptosis, and cellular senescence. As a DNA damage-inducing agent, doxorubicin... The content of this RSS Feed (c) The Royal Society of Chemistry
HDAC1 is involved in a form of DNA repair, but levels decline with age, as well as in Alzheimer's disease. This leads to a greater accumulation of unrepaired oxidative DNA damage in neurons. Researchers here note that increased activation of HDAC1 appears to improve cognitive function via a reduction in this oxidative DNA damage. An HDAC1 activator drug has been tested as a treatment for dementia, but caused serious side-effects. Better compounds or other approaches may be able to obtain similar benefits without the harms. There are several members of the HDAC family of enzymes, and their primary function is to m...
Condition: Mitral Regurgitation Functional Intervention: Device: MitraClip implantation Sponsor: IRCCS San Raffaele Recruiting
In this study, the resistant bacterial flora was screened from activated sludge and immobilized by sodium alginate (SAB). Nano-Fe3O4 was coated on biochar (BC@Fe3O4) to prevent agglomerating in soil. X-ray diffraction (XRD) and scanning electron microscope (SEM) were utilized to characterize BC@Fe3O4. Results demonstrated that the treatment of biochemical system (SAB + BC@Fe3O4 + PS) presented the maximum degradation rate about 92.56% within 24 days of incubation and improved soil microecology. The 16S rDNA sequences analysis of soil microorganisms showed a significantly different abundance and a simila...
Publication date: Available online 23 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Raina Sinha, Husnu Firat Altin, Courtney McCracken, Andrew Well, Joshua Rosenblum, Kirk Kanter, Brian Kogon, Bahaaldin Alsoufi
Publication date: Available online 23 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Alicia X.F. CHIA, Philip Y.K. PANG
Longaker Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the resident pancreas parenchymal cell repair program. Many solid tumor types including pancreatic cancer have severe tumor fibrosis called desmoplasia. Desmoplastic stroma is coopted by the tumor as a support structure and CAFs aid in tumor growth, invasion, and metastases. This stroma is caused by cancer associated fibroblasts (CAFs), which lay down extensive connective tissue in and around the tumor cells. CAFs represent a heterogeneous populat...
ConclusionThis study demonstrated that the nearer the tibial tunnel position to the anatomic attachment of the MM posterior root, the more effective the reduction in MMPE at 90 ° knee flexion. Our results emphasize that an anatomic tibial tunnel should be created in the MM posterior root to improve the postoperative MMPE and protect the articular cartilage in a knee flexion position. Placement of an anatomic tibial tunnel significantly improves the MMPE at 90° of knee fl exion after MM posterior root pullout repair.Level of evidenceIV.
Renal artery aneurysms (RAAs) are rare, with an incidence of20 mm has been generally accepted as the threshold for surgical repair.1–3 In particular, the presence of an aneurysm in the distal part of the renal artery constitutes a real challenge, as there are certain difficulties in preserving the blood supply to all branches of the renal artery.3 In this i ssue, Jayet et al. report their experience of using in situ repair techniques with direct reconstruction in patients operated on for a distal RAA.
We describe the clinical and surgical characteristics of gastroschisis patients in a Brazilian referral center.
In conclusion, the reported prevalence of scoliosis varies widely but on average affects about one in eight children after open repair of EA/TEF. Most cases are mild and do not require intervention. It is currently uncertain whether secondary scoliosis is preventable by using meticulous thoracotomy techniques or thoracoscopic repair.Level of evidence IV.