Melanocortin 5 receptor signaling pathway in health and disease.

Melanocortin 5 receptor signaling pathway in health and disease.
Cell Mol Life Sci. 2020 Apr 04;:
Authors: Xu Y, Guan X, Zhou R, Gong R
Abstract
Melanocortin hormone system plays a key role in maintaining the homeostasis of our body via their neuro-immune-endocrine activities and regulates a diverse array of physiological functions, including melanogenesis, inflammation, immunomodulation, adrenocortical steroidogenesis, hemodynamics, natriuresis, energy homeostasis, sexual function, and exocrine secretion. The pathobiologic actions of all melanocortins are conveyed by melanocortin receptors. As the last melanocortin receptor to be cloned and characterized, melanocortin receptor 5 (MC5R) is widely expressed in both central nervous system and a number of peripheral organ systems in man. However, the exact effect of the MC5R mediated melanocortinergic signaling remains largely uncertain. Owing to the recent advances in developing highly selective peptidomimetic agonists and antagonists of MC5R and also to studies in MC5R knockout animals, our understanding of MC5R pathobiology has been greatly expanded and strengthened. Evidence suggests that MC5R plays a key role in governing immune reaction and inflammatory response, and is pivotal for the regulation of sexual behavior, thermoregulation, and exocrine secretion, like sebogenesis, lacrimal secretion and release of sex pheromones. As such, recent translational efforts have focused on dev...

Source: Cellular and Molecular Life Sciences : CMLS - April 3, 2020 Category: Cytology Authors: Xu Y, Guan X, Zhou R, Gong R Tags: Cell Mol Life Sci Source Type: research