Maternal Thyroid Disorders and Risk of Autism Spectrum Disorder in Progeny

Conclusions: Results indicate that maternal thyroid conditions are associated with increased ASD risk in progeny, but suggestively not due to direct effects of thyroid hormones. Instead, factors that influence maternal thyroid function could have etiologic roles in ASD through pathways independent of maternal gestational thyroid hormones and thus be unaffected by medication treatment. Factors known to disrupt thyroid function should be examined for possible involvement in ASD etiology.
Source: Epidemiology - Category: Epidemiology Tags: Women’s Health Source Type: research

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Authors: Park YG, Choi J, Seol JW Abstract During pregnancy, the uterus undergoes intense neovascularization and vascular remodeling to supply oxygen and nutrients to the embryo. During this period, progesterone secreted from the ovary has effects on vascular remodeling in the endometrium and interacts with angiogenic factors. However, the exact mechanism of uterine vascular remodeling during pregnancy is poorly understood. Therefore, the aim of the present study was to investigate the association between angiopoietin-2 (Ang-2), one of the angiopoietins, and intrauterine vessel remodeling during pregnancy, and to d...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: August 2020Source: Research in Autism Spectrum Disorders, Volume 76Author(s): Phil Reed
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Publication date: August 2020Source: Research in Autism Spectrum Disorders, Volume 76Author(s): Sarah-Maude Coll, Nicholas E.V. Foster, Alexa Meilleur, Simona M. Brambati, Krista L. Hyde
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Publication date: August 2020Source: Research in Autism Spectrum Disorders, Volume 76Author(s): Susan M. Hayward, Keith R. McVilly, Mark A. Stokes
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 29 May 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Elisabetta Torlone, Camilla Festa, Gloria Formoso, Marina Scavini, Maria Angela Sculli, Elena Succurro, Laura Sciacca, Paolo Di Bartolo, Francesco Purrello, Annunziata Lapolla
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Conclusion: These observations definitively demonstrate an important role of PFN1 in mediating cell-cell adhesion during the initial stage of embryo implantation and suggest a potential therapeutic target or novel biomarker for patients suffering from implantation failure. PMID: 32466630 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
Authors: Wood SH, Sills ES Abstract The inverse correlation between maternal age and pregnancy rate represents a major challenge for reproductive endocrinology. The high embryo ploidy error rate in failed in vitro fertilization (IVF) cycles reflects genetic misfires accumulated by older oocytes over time. Despite the application of different follicular recruitment protocols during IVF, gonadotropin modifications are generally futile in addressing such damage. Even when additional oocytes are retrieved, quality is frequently poor. Older oocytes with serious cytoplasmic and/or chromosomal errors are often harvested f...
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Contributors : Diana Medina-Bastidas ; Ivan Salido-GuadarramaSeries Type : Expression profiling by arrayOrganism : Homo sapiensPreeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are major contributor of perinatal morbility and mortality, these pregnancy disorders associated with placental ischemia and share many similar pathophysiological features. The aim of this study was to compare the placental gene expression profiles including mRNA and lnRNAs from pregnant women from four study groups; PE, IUGR, PE-IUGR and normal pregnancy (NP). Gene expression microarray analysis was performed on placental tissue obtained...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
This article aims to provide an updated review of the most recent data around hormonal contraceptives and anti-retroviral therapy.Recent FindingsPrior data have suggested possible pharmacologic interactions between certain hormonal contraceptives and anti-retroviral therapy. The most significant interactions implicated include those between progestin-based contraceptive implants and efavirenz as well as between combined hormonal contraceptives and protease inhibitors. Most past studies, however, feature small sample sizes with few clinical outcomes reported.SummaryRecent data since 2017 have largely affirmed prior studies ...
Source: Current Obstetrics and Gynecology Reports - Category: OBGYN Source Type: research
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