IL ‐17A is produced by synovial fluid CD4+ but not CD8+ T cells after TCR activation and regulates different inflammatory mediators compared to TNF in a synovitis model of psoriatic arthritis

ConclusionPsA ‐SF CD8+ T‐cells, in contrast to CD4+ T‐cells, did not secrete IL‐17A after TCR activation. Overlapping but also distinct effects at the level of inflammatory cytokines and MMPs were found after neutralizing IL‐17A or TNFα in a humanex vivo PsA synovitis model.

Source: Arthritis and Rheumatology - April 2, 2020 Category: Rheumatology Authors: Xiaofei Xu, Nadine Davelaar, Anne ‐Marie Mus, Patrick S. Asmawidjaja, Johanna M.W. Hazes, Dominique L.P. Baeten, Marijn Vis, Radjesh J. Bisoendial, Errol P. Prens, Erik Lubberts Tags: FULL LENGTH Source Type: research