Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells (MoTrMyo)
Condition: Physical Activity Intervention: Other: Additional Muscle Biopsy Collection Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida Not yet recruiting
Authors: Xie Z, Chang C, Huang G, Zhou Z Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction between genetic alterations and environmental factors. More than 60 susceptible genes or loci of T1D have been identified. Among them, HLA regions are reported to contribute about 50% of genetic susceptibility in Caucasians. There are many environmental factors involved in the pathogenesis of T1D. Environmental factors may change the expression of genes through epigenetic mechanisms, thus inducing individuals with susceptible genes to develop T1D; however, the underlying mechanisms remain ...
Condition: Foot Ulcer, Diabetic Intervention: Other: No intervention Sponsors: Podimetrics, Inc.; American Association of Diabetes Educators Enrolling by invitation
Abstract More recent evidences are supportive of air pollution exposure on diabetes risk, including worsening of whole-body insulin sensitivity, enhancement of hepatic lipogenesis and nonalcoholic fatty liver disease after fine particulate matter (PM2.5) exposure. Therefore, we aimed to explore the lipidomics to get a comprehensive insight about ambient real-world PM2.5 exposure on lipid metabolism in blood and liver. After ambient PM2.5 exposure for 6 months, excess triglyceride accumulation in the liver was observed. Remarkable metabolic alterations including neutral lipids, glycerophospholipids and sphingolipid...
Publication date: Available online 23 May 2020Source: Neuroscience LettersAuthor(s): Chanan Meydan, Nurcan Üçeyler, Hermona Soreq
ConclusionTechnologies that evolve to include the characteristics described here will deliver more effective tools for patients, providers, payers, and policymakers and give patients control over sharing their data with those who need it in real time.
AbstractDiabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of ‘ketone bodies’ into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Dehydration, hyperglycemia, and ketoacidosis are the hallmarks of this condition. Treatment is effective repletion of ...
Publication date: Available online 23 May 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Arumugam Elangovan, Karuppaiah Sudha, Alagan Jeevika, Chandran Bhuvaneshwari, Palanisamy Kalimuthu, Vellaichamy Balakumar
Publication date: Available online 23 May 2020Source: Preventive MedicineAuthor(s): Soraya J. van Etten, Loes Crielaard, Mirthe Muilwijk, Irene van Valkengoed, Marieke B. Snijder, Karien Stronks, Mary Nicolaou