Limited Competition: National Biocontainment Laboratories (NBLs) Operations Support (UC7 Clinical Trial Not Allowed)
Funding Opportunity RFA-AI-20-026 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to continue to provide operations support for Biosafety Level 4 (BSL4) facilities to the National Biocontainment Laboratories at the University of Texas Medical Branch (UTMB) in Galveston, Texas and Boston University in Boston, Massachusetts. Operations support is provided in the following areas: facility maintenance and operations; biosecurity; environmental health and safety regulations and requirements; regulatory compliance; and specialized research support services. The NBLs will serve as a national resource for efforts in conducting pre-clinical and laboratory (in vitro and in vivo) research and testing on hazardous biological agents in support of NIAIDs biodefense and emerging infectious diseases research efforts. Additionally, in times of a national biodefense or emerging infectious disease (EID) emergency, the NBLs may be expected to rapidly realign their activities to assist response efforts within the US under the direction of NIAID.
CONCLUSION: The design results revealed that an optimum exposure of 1:2 of isopropanol: formaldehyde vapours for sixty minutes resulted in desired release of second pulse of dose after a predetermined lag time of 5 hours as desired. '3Cap' system was successful in achieving floating and pulsed release of hypertensive drug opening a 'new lease of life' to the existing drug molecule.
PMID: 32484113 [PubMed - as supplied by publisher]
A newly developed form of insulin which combines human insulin with fast acting venom insulin produced by sea snails may help improve treatments for diabetes, according to a study published inNature Structural and Molecular Biology.Science Daily
According to a study published inThe Journal of Clinical Endocrinology& Metabolism, obesity is not associated with an increased risk of developing thyroid disease or thyroid cancer.Endocrinology Advisor
According to a study published in theJournal of Clinical Endocrinology& Metabolism, exposure to PFAS chemicals found in water proof and non-stick products may speed up the onset of menopause in women. Medical Xpress
As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible therapies, resulting in a significant surge in demand. In overdose, both medications can cause severe, potentially life-threatening effects. Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations.
This study explored differences in patient classification of oxygen exposure by PaO2 cutoff and cumulative area-under-the-curve (AUC) analysis.
METHODS: Retrospective, explorative study including children (
Graham graduated from the School of Pharmacy, University of London, in 1964, and had a very varied career. In 1966 he became a lecturer in the Department of Ophthalmic Optics and Visual Science at City, University of London. While there, he undertook a PhD in “The pharmacology of the inferior oblique muscle of the rabbit” at St. Barthol omew’s Hospital Medical College.
We present a bulk motion detection and a linear time invariant (LTI) model-based motion correction approach for DCE-MRI alignment that leverages the temporal dynamics of the DCE data at each voxel. We evaluate our approach on 10 newborn patients that underwent DCE imaging without sedation. For each patient, we reconstructed the sequence of DCE images, detected and removed the volumes corrupted by motion using a self navigation approach, aligned the sequence using our approach and fitted the TK model to compute GFR. The results show that our approach correctly aligned all volumes and improved the TK model fit and, on averag...
Authors: Miceli A, Raffa S, Donegani MI, Cossu V, Morbelli S, Marini C, Sambuceti G, Bauckneht M
Sarcoidosis is a systemic inflammatory disease of unknown etiology, pathologically characterized by non-caseating granulomas involving several organs and tissues. This pathological process can eventually affect the heart during his course leading to fibrosis associated with systolic dysfunction, conduction disturbance, and even sudden cardiac death. Due to this prognostic impact, diagnosis is crucial to optimize clinical management. The low sensitivity of endomyocardial biopsy and its invasive nature prevents i...