Tumor necrosis factor α reduces gonadotropin-releasing hormone release through increase of forkhead box protein O1 activity

It has been found that hypothalamus helps to control aging, and hypothalamus-driven programmatic aging is associated with nuclear factor-κB (NF-κB)-mediated decrease of gonadotropin-releasing hormone (GnRH). However, the molecular mechanism(s) underlying aging-associated hypothalamic GnRH decline are largely unknown. Forkhead box O (FOXO), a family of transcription factors, has been demonstrated to be associated with aging. GnRH neuronal cell line GT1-7 was used in this study to determine whether FOXO1 was involved in tumor necrosis factor α (TNF-α)-induced decrease of GnRH. Our data showed that FOXO1 activity was increased by TNF-α through inhibition of its phosphorylation. Increased FOXO1 activity inhibited gnrh1 gene and activated NF-κB, thereby impairing the secretion of GnRH from GT1-7 cells. The increase of FOXO1 activity contributes to TNF-α-induced decrease of GnRH release, which may underscore the significance of this event to the development of aging and therapeutic interventions against age-dependent pathologies.
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research

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CONCLUSIONS: Platelet count, a marker of vascular repair capability, appears to modify the relationship between handgrip strength and CMBs. PMID: 32477460 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Abstract There is much interest in targeting DNA repair pathways for use in cancer therapy, as the effectiveness of many therapeutic agents relies on their ability to cause damage to DNA, and deficiencies in DSB repair pathways can make cells more sensitive to specific cancer therapies. For example, defects in the double-strand break (DSB) pathways, non-homologous end joining (NHEJ) and homology-directed repair (HDR), induce sensitivity to radiation therapy and poly(ADP)-ribose polymerase (PARP) inhibitors, respectively. However, traditional approaches to inhibit DNA repair through small molecule inhibitors have o...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
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Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Benjamin T. Dodsworth, Klas Hatje, Claas Aiko Meyer, Rowan Flynn, Sally A. Cowley
Source: Stem Cell Research - Category: Stem Cells Source Type: research
This article reviews tips and tricks to optimize the outcome of RSA when performed specifically for this indication.Recent FindingsRSA has been reported to provide satisfactory outcomes in a large proportion of patients with FIRCTs. However, subjective satisfaction is lesser in patients with well-maintained preoperative motion as well as those with isolated loss of active external rotation. The popularity of implants that provide some degree of global lateralization continues to increase. Optimizing the outcome of RSA for FIRCTs requires a careful balance between minimizing perimeter impingement and enhancing the function ...
Source: Current Reviews in Musculoskeletal Medicine - Category: Orthopaedics Source Type: research
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Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
BACKGROUND: Pediatric outcomes after flexor tendon repairs are variable, and evidence in the literature remains scarce. METHODS: Repair of pediatric flexor tendon injuries was reviewed over a 10-year period (2005-2015). Data collection consisted of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Achilles tendon rupture is an increasingly common problem with an aging population participating in high-level physical activities. Appropriate treatment has been debated for decades, but good outcomes have been reported after conservative and surgical management. The development of minimally invasive surgical techniques for Achilles repair has reduced the incidence of complications and maintained the high level of function reported after open surgery. The Achilles Midsubstance SpeedBridge repair is a newer minimally invasive technique that has demonstrated promising results and is the authors ’ preferred treatment o...
Source: Orthopedic Clinics of North America - Category: Orthopaedics Authors: Source Type: research
Identification of DNA repair mutations singles out patients with advanced pancreatic cancer who respond best to first-line platinum chemotherapy.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
  At the thought of losing a job or missing a mortgage payment, Gabe is an anxious discombobulated mess, while Lisa is cool as a cucumber. In today’s Not Crazy podcast, Gabe and Lisa ponder: Why do people have such vastly different ways of reacting to the world? They also discuss — with the special flare that only a divorced couple has — the good old days when Gabe would have full-blown panic attacks and Lisa had to get them through it. How did they handle these scary moments? Is it ever OK to feel anger toward the panicky person? And what if the panicky person accidentally causes harm — sh...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General LifeHelper Mental Health and Wellness Not Crazy Podcast Source Type: blogs
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