Regulation of filamentation by bacteria and its impact on the productivity of compounds in biotechnological processes.

Regulation of filamentation by bacteria and its impact on the productivity of compounds in biotechnological processes. Appl Microbiol Biotechnol. 2020 Apr 03;: Authors: Rizzo MG, De Plano LM, Franco D Abstract The bacteria wall fulfills important physiological functions at the cell, depending on its composition and organization. Many researches focused their studies in understanding the change of its properties not only in strength and permeability, but also in morphological plasticity due to both chemical and physical stresses. In particular, filamentation morphology is a cryptic phenomenon, with involve for great variety of bacteria, which allow them to acquire adaptive benefits. This phenotypic alteration consists of an alteration or lack of cell septation during the cell growth, as consequence of DNA damage or development of stress, such as nutritional factors, antibiotic resistance, low temperature, non-availability of oxygen, high osmolarity, and antimicrobial agents. These cells result in modification of elongation 10-50 times, thickness, chemical composition, and extent of cross-linking of the cell wall polymers than normal-shaped cells. Moreover, the advancement in the morphology engineering permitted the manipulation of the genes encoding the proteins belonging to the plasma membrane or cytoplasm, to have the control over the bacterial shapes and of the its cytoplasmatic environment. In biotechnology application, the intrac...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research