Advanced carcinoma of the oropharynx: survival analysis comparing two treatment modalities

The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Medical records of patients were reviewed. Previously treated tumors were excluded. Clinical, demographic and microscopic information was collected, and p16 staining was performed. Kaplan-Meier survival curves were plotted. Forty-seven cases were included, 41 men and 6 women, having a mean age of 56.3 years. Most patients were smokers (85.1%) and consumed alcohol (74.5%). Patients were stage III (21.3%) or IV (78.7%). Most lesions affected the base of the tongue (36.2%). Of the 23 cases available for p16 testing, 3 were positive (13.0%). There was no difference between the overall and the disease-free survival rates for the two treatment modalities (p>0.05), even when only resectable tumors were compared. Seventeen cases experienced recurrence (36.2%); 16 (34.0%) patients remained alive without disease; 15 (31.9%) died due to disease; 9 (19.2%) were recurrent at the last follow-up. The two treatment protocols were equally efficient in treating advanced oropharynx squamous cell carcinoma, since both promoted similar overall and disease-free survival rates. The results and interpretations related herein mostly regard “ conventional ” oropharyngeal squamous cell carcinomas, as opposed to HPV-associated tumors.
Source: Brazilian Oral Research - Category: Dentistry Source Type: research

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Conclusion: Head and neck cancers are the third most common cancer in Bhutan after stomach cancer and cervical cancer. Thyroid, oral cavity and hypopharynx are the top three anatomical sites for head and neck cancers in Bhutan. The current epidemiological and histopathological profile of head and neck cancers will form a baseline of information and basis for further research on head and neck cancers in Bhutan. PMID: 32346390 [PubMed]
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
o Muto Ionna : Head and neck squamous cell carcinomas (HNSCCs) are a very heterogeneous group of malignancies arising from the upper aerodigestive tract. They show different clinical behaviors depending on their origin site and genetics. Several data support the existence of at least two genetically different types of HNSCC, one virus-related and the other alcohol and/or tobacco and oral trauma-related, which show both clinical and biological opposite features. In fact, human papillomavirus (HPV)-related HNSCCs, which are mainly located in the oropharynx, are characterized by better prognosis and response to ther...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC). MATERIAL AND METHODS: Cross-sectional study based on the records of 404 OOSCC patients evaluated for DM, covering the period 2000-2014. We analysed the influence of age, sex, level of schooling, primary tumor subsite, treatment, marital status, family history of cancer, history of smoking and alcohol consumption, type of health care coverage (private vs. public) and ov...
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
ConclusionThe incidence of de novo malignancy was 1% at a median follow up of 42 (32-73) months. De novo malignancies following LDLT, although uncommon, are associated with significant mortality. A careful screening protocol should be followed post transplantation for early detection of de novo malignancies.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
This report describes the case of OSCC in a 60-year-old black man, a smoker and chronic alcoholic, who complained of “pain when swallowing.” A left cervical lymph node measuring 3.0 cm that was fixed and painless was observed at the extraoral examination. Intraoral examination revealed a bleeding hard ulcer with raised edges that was painful to palpation, 6.0 cm in diameter, and located in the left soft palate with 6 months of evolution.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
ConclusionPre-treatment panendoscopy can reveal synchronous malignancies of the upper aerodigestive tract in patients with primary oral squamous cell carcinoma. Risk stratification of patients can avoid unnecessarily conducted panendoscopy in patients without risk factors. This may lead to a higher cost-efficacy in public health system, less treatment-related complications and earlier treatment initiation.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 21 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Shengming Xu, Bao Sun, Rong Zhou, Chaoji Shi, Yong Han, Jiayi Li, Jingjing Sun, Zhen Tian, Zhiyuan Zhang, Jiang LiAbstractObjectives: To characterize the clinicopathological features of Oropharyngeal Squamous Cell Carcinoma (OPSCC) patients from an eastern Chinese population and evaluate the diagnostic validity of P16 immunochemistry (IHC) for HPV status detection in OPSCC.Study Design: A total of 257 paraffin-embedded primary OPSCC specimens were collected from 2014 to 2019. HPV RNA In-Situ-H...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 12 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S.N. Rogers, A. Swain, C. Carroll, D. LoweAbstractAfter their initial presentation of oral squamous cell carcinoma (SCC), patients have a lifelong risk of developing another new SCC of the head and neck. The aim of this study was to establish second primary rates, baseline characteristics (site, clinical or pathological stage, and smoking and alcohol history), timing, presentation, treatment, and outcomes. From the regional unit we analysed records of patients treated with curative intent for their first or...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionsThe primary endpoint was met. LRC rate and PFS significantly improved when Debio 1143 was added to standard CRT in high-risk SCCHN patients. A trend in OS improvement was observed and additional follow-up will provide more mature OS/PFS data. Debio 1143 addition was feasible, safe and did not compromise backbone therapy. These promising results need to be confirmed in a larger phase III study.Clinical trial identificationEudraCT: 2013-000044-25.Editorial acknowledgementMarina Leroy and Berit Sund, from Weber Shandwick.Legal entity responsible for the studyGORTEC group and Debiopharm International SA GORTEC and D...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Studies are essential for education and awareness aimed at reducing exposure to habit-forming substances.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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