Metformin revert insulin ‐induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells

ConclusionsInsulin ‐induced oxaliplatin resistance was reversed by metformin‐mediated AMPK activation. Accordingly, metformin is likely to sensitize patients with diabetes to chemotherapeutic drugs used to treat colon cancer.

Source: Cancer Medicine - April 4, 2020 Category: Cancer & Oncology Authors: Chao Liu, Qianqian Liu, Aiwen Yan, Hui Chang, Yuyin Ding, Junye Tao, Chen Qiao Tags: ORIGINAL RESEARCH Source Type: research