DNA repair and metabolic gene polymorphisms affect genetic damage due to diesel engine exhaust exposure.

DNA repair and metabolic gene polymorphisms affect genetic damage due to diesel engine exhaust exposure. Environ Sci Pollut Res Int. 2020 Apr 03;: Authors: León-Mejía G, Quintana-Sosa M, de Moya Hernandez Y, Rodríguez IL, Trindade C, Romero MA, Luna-Carrascal J, Ortíz LO, Acosta-Hoyos A, Ruiz-Benitez M, Valencia KF, Rohr P, da Silva J, Henriques JAP Abstract Diesel engine exhaust (DEE) is a complex mixture of toxic gases, halogenated aromatic hydrocarbons, alkyl polycyclic aromatic hydrocarbons, polycyclic aromatic hydrocarbons, benzene derivatives, metals and diesel exhaust particles (DEPs) generated from the incomplete combustion of diesel fuel. Many of the compounds in this mixture can cause oxidative damage to DNA and are considered carcinogenic for humans. Further, chronic DEE exposure increases risks of cardiovascular and pulmonary diseases. Despite these pervasive health risks, there is limited and inconsistent information regarding genetic factors conferring susceptibility or resistance to DEE genotoxicity. The present study evaluated the effects of polymorphisms in two base excision repair (BER) genes (OGG1 Ser326Cys and XRCC1 Arg280His), one homologous recombination (HRR) gene (XRCC3 Thr241Met) and two xenobiotic metabolism genes (GSTM1 and GSTT1) on the genotoxicity profiles among 123 mechanics exposed to workplace DEE. Polymorphisms were determined by PCR-RFLP. In comet assay, individuals with the GSTT1 null genotype ...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research