Luliconazole, a highly effective imidazole, against Fusarium species complexes

In this study, 47 isolates ofFusarium were tested against several antifungals including luliconazole. All species were identified using morphology features, and PCR sequencing and antifungal susceptibility were performed according to CLSIM38 A3 guideline. Our results revealed that luliconazole has a very low minimum inhibitory concentration value (0.0078 –1 µg/ml) in comparison with other tested antifungals. Amphotericin B had a poor effect with a high MIC90 (64  µg/ml), followed by terbinafine (32 µg/ml), posaconazole (16 µg/ml), caspofungin (16 µg/ml), voriconazole (4 µg/ml), and itraconazole (4 µg/ml). Overall, our findings indicated that luliconazole has great activity against environmental and clinicalFusarium species complexes in comparison to tested antifungals.
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research