Chronic myeloid leukemia may no longer be a contraindication to lung transplantation

Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell proliferation caused by a constitutively active tyrosine kinase called BCR-ABL. The BCR-ABL fusion gene results from a translocation between chromosomes 9 and 22. The development of targeted tyrosine kinase inhibitors (TKIs) has transformed this previously fatal illness into a chronic disease.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research