Alvimopan is Associated with a Reduction in Length of Stay and Hospital Costs for Patients Undergoing Radical Cystectomy
To evaluate the impact of alvimopan in patient undergoing radical cystectomy (RC) for bladder cancer. We hypothesize that alvimopan can decrease cost for RC by reducing length of stay (LOS).
Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature ...
Here are the most important stories that Medscape Oncology's editors picked for you to read today.Medscape Medical News
On April 20, the president calls a press conference to announce a breakthrough in the fight against COVID-19. It’s a new use for an old malaria treatment, he says, one that is seeing miraculous results among the country’s most ill patients. It’s so safe that even schoolchildren could take it. In fact, he urges them to do so daily, as a preventative. He admits that he, too, is taking the medicine. No, this is not the President of the United States touting an unproven remedy for a virus that has infected nearly 5 million people worldwide. It is Madagascar’s President Andry Rajoelina, who is just as wi...
CONCLUSIONS: ZNFX1-AS1 regulated bladder cancer progression by targeting the miR-193a-3p/SDC1 axis. Our study may provide novel insights for bladder cancer prognosis and therapy. PMID: 32432735 [PubMed - in process]
High-risk bladder cancer post-surgery follow-up is intensive and based on expert opinion. A new study questions that intensity and opinion.Medscape Medical News
Nature Reviews Urology, Published online: 22 May 2020; doi:10.1038/s41585-020-0339-3Bladder cancer outcomes differ between men and women. Elucidating this sexual dimorphism, genomic analyses found differing molecular subtype distributions and androgen response activities in muscle-invasive bladder cancer in men and women. Together with knowledge of cancer driver genes, biomarkers and clinical characteristics, these findings will hopefully lead to sex-based personalized research and management of bladder cancer.
In this study, we have investigated the relationship between circRNA expression and tumor grade in a cohort of 58, mostly non-muscle-invasive bladder cancer patients. From 4571 circRNAs detected, we identified 157 that were significantly differentially expressed between tumor grades relative to the linear transcript. We demonstrated that such grade-related differences can be identified in an independent cohort, and that a large fraction of circRNAs can be, in principle, detected in urine. The differentially expressed circRNAs cluster into subgroups according to their co-expression, subgroups which are enriched for DNA repa...
ConclusionsOur data should help guiding the selection of targeted therapies for investigation in future clinical trials and, additionally, may provide a basis for prospective mechanistic studies of pTa HG pathogenesis.
Conclusions: Although systemic intra-venous application of ICG and negative-staining of the rectum including the mesorectum is much easier compared to laparoscopic inter-arterial perfusion through IMA, image results of selevtive IMA-perfusion appear in sharper discrimination of the several layers. Further investigation should focus on simplifying this technique. PMID: 32425093 [PubMed - as supplied by publisher]
Conclusions: A high BMI, a short height, excess BMI gain in childhood and low and high birth weights are associated with increased hazards of BC. PMID: 32429767 [PubMed - in process]