Patient-Derived Orthotopic Xenograft models in gastric cancer: a systematic review

AbstractPatient-Derived Xenografts (PDXs) are, so far, the best preclinical model to validate targets and predictors of response to therapy. While subcutaneous implantation very rarely allows metastatic dissemination, orthotopic implantation (Patient-Derived Orthotopic Xenograft —PDOX) increases metastatic capability. Using a modified tool to analyze model validity, we performed a systematic review of Embase, PubMed, and Web of Science up to December 2018 to identify all original publications describing gastric cancer (GC) PDOXs. We identified ten studies of PDOX model va lidation from January 1981 to December 2018 that fulfilled the inclusion and exclusion criteria. Most models (70%) were derived from human GC cell lines rather than tissue fragments. In 90% of studies, the implantation was performed in the subserosal layer. Tumour engraftment rate ranged from 0 to 1 00%, despite the technique. Metastases were observed in 40% of PDOX models implanted into the subserosal layer, employing either cell suspension or cell line-derived tumour fragments. According to our modified model validity tool, half of the studies were defined as unclear because one or more valid ation criteria were not reported. Available GC PDOX models are not adequate according to our model validity tool. There is no demonstration that the submucosal site is more effective than the subserosal layer, and that tissue fragments are better than cell suspensions for successful engraftment and metastatic sp...
Source: Updates in Surgery - Category: Surgery Source Type: research

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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Contributors : Leah M Rommereim ; Bhaskar Dutta ; Ajay S Akhade ; Carolyn Hutcheon ; Nicolas W Lounsbury ; Clifford C Rostomily ; Iain D Fraser ; Ronald N Germain ; Naeha SubramanianSeries Type : Expression profiling by arrayOrganism : Homo sapiensAltered protein dosage by defects in single genes leads to haploinsufficiencies and monogenic disorders, but the impact of small changes in gene expression on multifactorial disease is unknown. Here we show that a persistent small increase in expression of NOD1, a key innate sensor of bacterial infection, precipitates a large physiological effect with dramatically altered cellula...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
AbstractPurposeAging societies comprise an increasing number of elderly gastric cancer (GC) patients. We herein attempted to determine whether D2 lymphadenectomy is beneficial for older GC patients.MethodsWe retrospectively analyzed a multi-institutional dataset including 3484 patients who received surgical resection for GC. For the analysis, we selected patients aged  ≥ 80 years who were clinically diagnosed with T1N + or T2-4 GC. To balance the essential variables including the type of gastrectomy and the stage of progression, propensity score matching was conducted, and we compared th...
Source: Surgery Today - Category: Surgery Source Type: research
Publication date: Available online 23 May 2020Source: Meta GeneAuthor(s): Tayabeh Salehnezhad, Fatemeh Hajati, Zabih Mir Hassani, Farbod Esfandi, Vahid Kholghi-Oskooei, Mohammad Taheri, Soudeh Ghafouri-Fard, Majid Samsami
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 23 May 2020Source: Respiratory Medicine Case ReportsAuthor(s): Yuki Abe, Masaru Suzuki, Kosuke Tsuji, Mineyoshi Sato, Hirokazu Kimura, Hiroki Kimura, Kentaro Nagaoka, Emi Takakuwa, Yoshihiro Matsuno, Satoshi Konno
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
CONCLUSIONS Upregulation of FAM3B triggered CDDP resistance in gastric cancer cells by inducing EMT in a snail-dependent manner, making FAM3B a promising therapeutic target to reverse gastric cancer chemo-resistance. PMID: 32442162 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qiang Zhang, Xiaobing Wang, Shijie Cao, Yujie Sun, Xinya He, Benke Jiang, Yaqin Yu, Jingshi Duan, Feng Qiu, Ning Kang
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relations...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Programmed death-ligand 1 (PD-L1) expression determines the eligibility for anti-PD-1 treatment in patients with advanced gastric cancer, but evidence indicates that PD-L1 staining is heterogeneous. Patients w...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
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