Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

ConclusionsDue to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research

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Authors: Watahiki T, Okada K, Warabi E, Nagaoka T, Suzuki H, Ishige K, Yanagawa T, Takahashi S, Mizokami Y, Tokushige K, Ariizumi SI, Yamamoto M, Shoda J Abstract Gender and menopause influence the severity and development manner of nonalcoholic steatohepatitis (NASH). Male p62/Sqstm1 and nuclear factor E2-related factor-2 (p62 and Nrf2) double-knockout (DKO) mice exhibit severe steatohepatitis caused by hyperphagia-induced obesity, overload of lipopolysaccharide (LPS) into the liver, and potentiation of the inflammatory response in Kupffer cells. However, the pathogenetic phenotype of steatohepatitis in female DKO...
Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
Publication date: Available online 3 June 2020Source: Life SciencesAuthor(s): Wahid Ali Khan, Arshi Malik, Mohd. Wajid Ali Khan
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 2 June 2020Source: Life SciencesAuthor(s): Fereshteh Yazdanpanah, Michael R. Hamblin, Nima Rezaei
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 2 June 2020Source: Life SciencesAuthor(s): Ying Luo, Yue Tian, Chunrong Zhao
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 1 September 2020Source: Life Sciences, Volume 256Author(s): Fedor Simko, Russel J. Reiter
Source: Life Sciences - Category: Biology Source Type: research
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
When it comes to health concerns, the COVID-19 pandemic is top of mind for most people right now. And that’s for good reason. But there is some very good non-COVID health news that may not be getting the attention it deserves. According to the CDC, the rates of six of the top 10 causes of death in this country, which account for about three-quarters of all deaths, have been declining. That’s remarkable. And these improvements are occurring despite an aging population and an obesity epidemic that affects several health conditions. Six positive health trends Let’s look at the trends in these conditions...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Health Health trends Heart Health Source Type: blogs
By Joseph ChamieNEW YORK, May 4 2020 (IPS) How many COVID-19 deaths will occur before a vaccine becomes available worldwide? As with many seemingly simple questions about an uncertain future, the proper answer to that important query is: “it depends”. The total worldwide number of deaths from COVID-19 before a vaccine, reported to be nearly a quarter-million at the end of April and amounting to a five-fold increase since the start of April, is hard to predict. It depends on a host of critical factors, many of which are not well understood and are changing rapidly. In the absence of a vaccine and limited success...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health TerraViva United Nations Source Type: news
One of the worst symptoms of any plague is uncertainty—who it will strike, when it will end, why it began. Merely understanding a pandemic does not stop it, but an informed public can help curb its impact and slow its spread. It can also provide a certain ease of mind in a decidedly uneasy time. Here are some of the most frequently asked questions about the COVID-19 pandemic from TIME’s readers, along with the best and most current answers science can provide. A note about our sourcing: While there are many, many studies underway investigating COVID-19 and SARS-CoV-19, the novel coronavirus that causes the illn...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Explainer Source Type: news
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