An epidemiological study exploring a possible impact of treatment with ACE inhibitors or angiotensin receptor blockers on ACE2 plasma concentrations

The current SARS-CoV-2 pandemic has high fatality rates and imposes increasingly severe social and economic impacts worldwide. Covid-19 patients with cardiovascular disease are at increased risk of death. They are very often treated with drugs targeting the renin-angiotensin-aldosterone system, where angiotensin converting enzyme (ACE) is of particularly importance. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) are standard therapies for high blood pressure and heart failure (HF) and currently prescribed to more than 25 Mio people in Germany alone (approx.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research

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Hey everyone, Hope you're all staying safe during this pandemic. I am a medical student who was supposed to graduate this month but the graduation got delayed for 2 months. Staying home during this pandemic allowed me to think and reevaluate my decisions. This lead me to road block when I wanted to choose a specialty. I've always wanted pediatrics. After my pediatrics rotation I started to enjoy other rotations even less. However, I also enjoyed the pediatric surgery rotation. Dealing with... Choosing A Specialty That Fits
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums
Publication date: Available online 25 May 2020Source: Journal of the American College of RadiologyAuthor(s): Sherry S. Wang, Marilyn A. Roubidoux
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Publication date: Available online 25 May 2020Source: Academic RadiologyAuthor(s): Amel Amalou, Baris Turkbey, Sheng Xu, Evrim Turkbey, Peng An, Gianpaolo Carrafiello, Anna Maria Ierardi, Robert Suh, Hayet Amalou, Bradford J. Wood
Source: Academic Radiology - Category: Radiology Source Type: research
Authors: Tung-Chen Y PMID: 32446685 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Pérez-Suárez B, Martínez-Menchón T, Cutillas-Marco E PMID: 32446684 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: López Castro J PMID: 32446683 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractCOVID 19 is much more than an infectious disease by SARS-CoV-2 followed by a disproportionate immune response. An older age, diabetes and history of cardiovascular disease, especially hypertension, but also chronic heart failure and coronary artery disease among others, are between the most important risk factors. In addition, during the hospitalization both hyperglycaemia and heart failure are frequent. Less frequent are acute coronary syndrome, arrhythmias and stroke. Accordingly, not all prolonged stays or even deaths are due directly to SARS-CoV-2. To our knowledge, this is the first review, focusing both on ca...
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
CONCLUSION In this regards, more laboratory and clinical evidences are required in order to decide COVID-19 treatment. In conclusion to this debate, suggesting roles of antihypertensive agents and severity leading changes in ACE2 levels, may shed more light on infectivity and outcome of COVID-19.There is an urgent need to establish whether treatments with antihypertensive (ACEI's/ ARBs) needs to be determined. PMID: 32389117 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
Abstract Corona Virus Disease 2019 (COVID-19) pandemic has impacted health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with pre-existing cardiovascular (CV) disease, hypertension, and related conditions incur disproportionately worse outcome. The high infectivity of the SARS-CoV-2 virus is in part related to new mutations in the receptor binding domain, and acquisition of a furin cleavage site in the S spike protein. The continued viral shedding in the asymptomatic and pre-symptomatic individuals enhances its community transmission. The virus uses the ACE2 re...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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