What Causes Acute Urticaria?
Discussion Urticaria or hives is a systemic disease with cutaneous results. An agent triggers a histamine reaction with cutaneous pruritic lesions being the result. Urticaria usually has intact, erythematous lesions with a papular component that is usually paler in color. Lesions are of various sizes and wax and wane. The lesions may coalesce and blanch with pressure. Scratches and excoriations may be seen. Bullae can be seen in certain circumstances. Evaluation for systemic reaction is important such as hoarseness, stridor, wheezing, difficulty breathing, arrhythmias, difficulty swallowing or tingling. Acute urticaria is defined as urticaria for less than 6 weeks. Chronic urticaria is defined as wheals that occur at least twice weekly for more than 6 weeks. Because this is a broad definition, some people add that the wheals must be present for more than 1 hour (which distinguishes chronic urticaria from dermatographism) and less than 24-36 hours (which distinguishes it from urticaria-vasculitis). The maintstays of treatment are antihistamines, short-acting ones for acute urticaria and long-acting ones for chronic urticaria. Mastocytosis or angioedema may appear similar to urticaria but are different. Angioedema frequently occurs in mucous membranes and may or may not have urticarial wheals present. Mastocytosis is a heterogeneous group of mast cell disorders which may cause wheal-like lesions on the skin. Learning Point The most common cause of acute urticaria is respirato...
Conclusion: These results suggested F127/TPGS-MMs might be a potential nanocarrier for oral delivery of GL. PMID: 32463722 [PubMed - as supplied by publisher]
Condition: Food Allergy in Children Intervention: Diagnostic Test: skin prick-test Sponsor: Central Hospital, Nancy, France Not yet recruiting
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CONCLUSION: Ultra-widefield imaging is a very helpful tool in the management of a patient with Eales'disease. PMID: 32463328 [PubMed - as supplied by publisher]
CONCLUSIONS: TINU occurs in all age groups. Posterior segment manifestations are common. Most patients required systemic steroid therapy, with a significant number requiring long-term systemic immunomodulation. Careful fundus examination is required on all patients with TINU. PMID: 32463299 [PubMed - as supplied by publisher]
Abstract Glycerol is widely used as humectant in cosmetics to improve skin's smoothness and moisture. However, its level must be controlled in cosmetics at the risk of causing irritation or allergy. Therefore, determining glycerol concentration in environmental waters with more advanced, inexpensive and accurate sensing systems is of great importance. In this work, a fast, simple, portable and cheap molecular imprinted polymer (MIP) approach is used to develop an electrochemical sensor for glycerol determination. The MIP based screen-printed gold electrode (Au-SPE) is prepared by electro-polymerizing Acrylamide/Bi...
Discussions with the FDA are ongoing to define the required data set for filing Janssen’s Ebola vaccine regimen under the FDA’s Animal Rule licensure pathway. About Janssen’s Ebola Vaccine Regimen The Janssen investigational preventive Ebola vaccine regimen (Ad26.ZEBOV, MVA-BN-Filo) utilizes a viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors are modified to safely carry the genetic code of an Ebola virus protein in order...
A 41-year-old man came to the emergency department because of the sudden onset of palpitations and dizziness. It started when he was celebrating the championship of his soccer team in a pub nearby. As shown in Figure 1A, during the registration of a 12-lead electrocardiogram (ECG) in the first heart aid clinic, a regular wide QRS tachycardia suddenly accelerated accompanied by a drop in blood pressure. The emergency physician terminated the arrhythmia by electrical cardioversion. Figure 1B shows the ECG there after.
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