Dengue hemorrhagic fever – A systemic literature review of current perspectives on pathogenesis, prevention and control

Publication date: Available online 26 March 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Wen-Hung Wang, Aspiro Nayim Urbina, Max R. Chang, Wanchai Assavalapsakul, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research

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Santos Nuovo Oliveira Paes Dengue is an arboviral disease caused by dengue virus (DENV), which is transmitted to humans by Aedes aegypti mosquitoes. Infection by DENV most commonly results in a mild flu-like illness; however, the disease has been increasingly associated with neurological symptomatology. This association draws attention to further investigations on the impact of DENV infection in the host’s central nervous system. Here, we analyzed brain samples of three fatal dengue cases that occurred in 2002 during an outbreak in Rio de Janeiro, Brazil. Brain tissues of these cases were marked by ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Crisanta Serrano-Collazo, Erick X. P érez-Guzmán, Petraleigh Pantoja, Mariah A. Hassert, Idia V. Rodríguez, Luis Giavedoni, Vida Hodara, Laura Parodi, Lorna Cruz, Teresa Arana, Melween I. Martínez, Laura White, James D. Brien, Aravinda de Silva, Amelia K. Pinto, Carlos A. Sariol Little is known about the contribution of virus-specific and cross-reacting antibodies (Abs) or the cellular immune response generated by a primary dengue (DENV) infection on the course of a secondary zika (ZIKV) infectionin vivo. Here we show that the length of time between DENV/ZIKV infections has a qualitative imp...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Laura B. Dickson, Sarah H. Merkling, Mathieu Gautier, Amine Ghozlane, Davy Jiolle, Christophe Paupy, Diego Ayala, Isabelle Moltini-Conclois, Albin Fontaine, Louis Lambrechts Although specific interactions between host and pathogen genotypes have been well documented in invertebrates, the identification of host genes involved in discriminating pathogen genotypes remains a challenge. In the mosquitoAedes aegypti, the main dengue virus (DENV) vector worldwide, statistical associations between host genetic markers and DENV types or strains were previously detected, but the host genes underlying this genetic specificity hav...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Abstract Aedes (Stegomyia) aegypti is a cosmopolitan species that transmits arbovirus of medical importance as dengue, Zika, and chikungunya. The main strategy employed for the control of this mosquito is the use of larvicidal agents. However, the overuse of synthetic chemical larvicides has led to an increase in resistant insects, making management difficult. Therefore, the use of botanical insecticide-based nanosystems as an alternative to the use of synthetic agents for the control of Ae. aegypti has gained more considerable attention in the last years, mainly due to the advantages of nanostructured delivery sy...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
er JJ Abstract Real-time reverse transcriptase PCR (rRT-PCR) is the most accurate method for the detection of dengue virus (DENV) and yellow fever virus (YFV) in acute illness. However, performing rRT-PCR is not feasible for many laboratories in regions of endemicity. The current study compared new reverse transcription-insulated isothermal PCRs (the POCKIT DENV and YFV reagent sets) with laboratory-developed rRT-PCRs for both viruses using clinical samples and viral strains from different endemic regions. Sensitivity and specificity of the POCKIT DENV Reagent Set were 87.2% (68/78 samples) and 98.2% of samples (5...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Carlos Daniel Cordero-Rivera Arianna M. Hurtado-Monzón Fernando Ruíz-Jiménez Ana Lorena Gutiérrez-Escolano Rosa María del Ángel During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) and Zika virus (ZIKV). We found that while during DENV infection the integrity and distribution of at least three nucleoporins (Nup), N...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The AWED (Applying Wolbachia to Eliminate Dengue) trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Yogyakarta, Indonesia, with the aim of measuring the efficacy o...
Source: Trials - Category: General Medicine Authors: Tags: Update Source Type: research
ml;cken W Abstract Flaviviruses replicate in membranous factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus polyprotein integration contribute to ER stress and the host cell may exhibit an Unfolded Protein Response (UPR) to this protein accumulation, stimulating appropriate cellular responses such as adaptation, autophagy or cell death. These different stress responses support other antiviral strategies initiated by infected cells and can help to overcome viral infection. In epithelial A549 cells, a model currently used to study the flavivirus infection cycle and the host c...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Hohdatsu Feline infectious peritonitis (FIP) is a viral disease with a high morbidity and mortality by the FIP virus (FIPV, virulent feline coronavirus). Several antiviral drugs for FIP have been identified, but many of these are expensive and not available in veterinary medicine. Hydroxychloroquine (HCQ) is a drug approved by several countries to treat malaria and immune-mediated diseases in humans, and its antiviral effects on other viral infections (e.g., SARS-CoV-2, dengue virus) have been confirmed. We investigated whether HCQ in association with interferon-ω (IFN-ω) is effective for FIPV in v...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
va MM, Gomes CES Abstract The Dengue, Zika and Chikungunya viruses have been spreading in tropical regions, causing epidemics with high morbidity rates and fatal cases. The aim of this study was to assess the diversity and abundance of culicid species and the presence of arboviruses in mosquitoes, at the epicenter of an epidemic outbreak that occurred in people living near an urban Atlantic Forest park. Mosquitoes were captured with a Shannon trap between 2 and 6 pm in seven months of 2019. The Chikungunya virus was investigated according to the protocol described by Lanciotti (2007). The most abundant species wer...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
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