Safety and feasibility of PARP1/2 imaging with 18F-PARPi in patients with head and neck cancer.

CONCLUSIONS: Imaging of head and neck cancer with 18F-PARPi is feasible and safe. 18F-PARPi detects primary and metastatic lesions, and retention in tumors is longer than in healthy tissues. PMID: 32245901 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

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CONCLUSIONS: All local nodal recurrences occurred at sites that received high radiotherapy doses and doses received by sites of eventual failure did not vary significantly from sites that remain in control. PMID: 32484037 [PubMed - in process]
Source: Technology in Cancer Research and Treatment - Category: Cancer & Oncology Authors: Tags: Technol Cancer Res Treat Source Type: research
Publication date: Available online 15 July 2019Source: European Journal of RadiologyAuthor(s): Felix Feldhaus, Georg Böning, Martin Jonczyk, Johannes Kahn, Uli Fehrenbach, M. Maurer, D. Renz, Bernd Hamm, Florian StreitparthAbstractPurposeWe determined whether the Smart MAR metal artifact reduction tool - a three-stage, projection-based, post processing algorithm - improves subjective and objective image quality and diagnostic confidence in patients with dental artifacts and suspected head and neck pathology compared to standard adaptive statistical iterative reconstructions (ASIR V) alone.MethodThe study included 100 ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusions: Catching errors prior to treatment is the only way to “chase zero” in radiation oncology. Various types of errors may exist in treatment plans and our GCPR model succeeds in preventing many errors of all shapes and sizes in target definition, dose prescriptions, and treatment plans from ever reaching the patients. Background and Introduction Since the release of the seminal report from the Institute of Medicine (IOM) titled, “To Err is Human,” in 1999, the importance of patient safety and avoiding medical errors have been recognized and endorsed by the physician community, as we...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionIn the RT planning strategy, the present findings support the use of PET/CT to improve upfront regional staging of HNC disease, particularly for oral cavity tumors. Further investigations are advocated to evaluate if this strategy could impact on long-term outcomes in terms of local control and overall survival.
Source: La Radiologia Medica - Category: Radiology Source Type: research
Abstract: Head and neck cancers have a very poor prognosis and are common in France. They are subject to various recommendations for early detection and management, but there is no detailed data in the French general population to fuel the public health debate on it. A high-resolution population-based study about cancer management was conducted, using cancers registries in the north-west of France, on 1729 tumors diagnosed between 2008 and 2010. The tumors were diagnosed late (70.3% stage III–IV), mainly after the onset of symptoms (93.2%). After adjustment, advanced stages were more frequent in patients with hypop...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Using PET/CT scans to assess response to therapy can help patients with head...Read more on AuntMinnie.comRelated Reading: 3-month PET/CT helps track oropharyngeal cancer Interrupted radiation therapy risks cancer recurrence PET/CT details hint at survival of head and neck cancer patients Oral HPV infection increasing in young men PET/CT prevents dissections for head and neck cancer patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A three-month follow-up PET/CT scan is very helpful for detecting the recurrence...Read more on AuntMinnie.comRelated Reading: Interrupted radiation therapy risks cancer recurrence PET/CT details hint at survival of head and neck cancer patients Oral HPV infection increasing in young men PET/CT prevents dissections for head and neck cancer patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Omami G, Tamimi D, Branstetter BF Abstract A combination of positron emission tomography (PET) with (18)F-labeled fluoro-2-deoxyglucose ((18)F-FDG) and computed tomography ((18)F-FDG-PET/CT) has increasingly become a widely used imaging modality for the diagnosis and management of head and neck cancer. On the basis of both recent literature and our professional experience, we present a set of principles with pictorial illustrations and clinical applications of FDG-PET/CT in the evaluation and management planning of squamous cell carcinoma of the oral cavity and oropharynx. We feel that this paper will be o...
Source: Imaging Science in Dentistry - Category: Dentistry Tags: Imaging Sci Dent Source Type: research
Conclusions A high incidence of artifacts was found on the planning scans of oral/oropharyngeal cancer patients, adversely impacting CTV visualization. In our phantom model, metal amalgam impacted tumor and tissue density. The PTV was underdosed with the metal amalgam compared with the composite filling. A potential solution involves exchanging metal fillings with composite before proton treatment planning for improved tumor visualization and dosimetry.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Weekly dose calculations do not seem to improve dose delivery for patients with tumors of the oral cavity, oropharynx, larynx and hypopharynx. In patients with nasopharyngeal carcinoma, however, mid-treatment imaging may facilitate DGRT. PMID: 26219958 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
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