MNA-SF is not sufficient without questioning protein and fruit –vegetable consumption to detect malnutrition risk in Parkinson’s Disease

AbstractMalnutrition risk (MR) prevalence in Parkinson ’s Disease (PD) is 3–60%. Mini-Nutritional Assessment (MNA) and MNA-SF are the widely Query used measurements for MR. The aim of this study was to identify if MNA-SF is sufficient to detect MR instead of total MNA in PD. Participants were compared in terms of anthropometric measurements, MNA (to tal, screening and evaluation), non-motor questionnaire, beck depression inventory, beck anxiety inventory. They were additionally compared according to evaluation part of MNA. All PD patients were divided into two groups as “with MR” and “without MR” according to total MNA scores and compar isons were done again. Then, IPD patients whose MNA-SF scores were normal were divided into another two subgroups as “with MR” and “without MR” according to total MNA scores and compared again. 58.7% PD patients and 28.6% controls were at MR. 32.5% PD patients whose MNA-SF scores were normal were detected as “with MR” by total MNA. MNA-SF had 87.1% sensitivity, 70.5% specificity, 67.5% positive predictive value, 88.6% negative predictive value and 77.3% accuracy in PD. PC and FVC were found to be the most important questions in MR estimation. Total MNA was sufficient to measure MR in PD, however MNA-SF missed many patients who were at MR. PC and FVC should be insistently questioned in addition to MNA-SF to find the accurate results of MR in PD patients, especially in femal...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research

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AbstractThe mechanisms underlying the neuroprotective effects of hesperidin in a murine model of PD are not fully elucidated. The current study was carried out to investigate the ability of hesperidin in modulating proinflammatory cytokines, neurotrophic factors, and neuronal recovery in 6-hydroxydopamine (6-OHDA)-induced nigral dopaminergic neuronal loss. Adult male C57BL/6 mice were randomly assigned into four groups: (I) sham/vehicle, (II) sham/hesperidin, (III) 6-OHDA/vehicle, and (IV) 6-OHDA/hesperidin. Mice received a unilateral intrastriatal injection of 6-OHDA and treated with hesperidin (50  mg/kg; per oral) ...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Affective disorders, in particular depression and anxiety, are common non-motor disorders in Parkinson's disease (PD). The burden of depression and anxiety has been studied in several clinical and research setting studies, and the reported prevalence ranges from 3% to 89% for depression1 and 7% to 55% for anxiety.2 Additionally, patients commonly present with both disorders.3 These disorders have negative impacts on disease outcomes; for example, depression in PD is associated with worse disability and health-related quality of life.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
ConclusionET-PD and ET-plus (PK) can be clinically difficult to differentiate  as they have overlapping motor and non-motor features.Beta-blocker use did not predict development of ET-PD or ET-plus (PK); however, anosmia and constipation may be helpful non-motor distinguishing features. DAT scans and levodopa trials may be valuable in clarifying the diagnoses.
Source: Neurological Sciences - Category: Neurology Source Type: research
Authors: Jenny AL, Meyer A, Handabaka I, Calabrese P, Fuhr P, Gschwandtner U Abstract Background: Parkinson's disease (PD) is associated with cognitive decline, progressing from subjective memory complaints (SMC) via mild cognitive impairment (MCI) to dementia. SMC are only measurable by an interview and thus rely on individuals reporting a subjectively perceived worsening of cognitive functioning. Cognitive decline is accompanied by a reduction in quality of life (QoL); however, the extent to which SMC manifest a reduction of QoL remains unclear. Objective: To determine the association between SMC and deterior...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
CONCLUSIONS: This meta-analysis revealed that cognitive behavioral therapy is effective in relieving depression and anxiety of patients with Parkinson's disease. Medical workers could apply cognitive behavioral therapy into daily routine cares for patients with Parkinson's disease. More studies with high quality and follow-up assessment on this topic are still required. PMID: 32379650 [PubMed - as supplied by publisher]
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
Abstract Non-motor symptoms (NMS) including sleep disorders, anxiety, depression, fatigue, and cognitive decline can significantly impact quality of life in people with PD. Qigong exercise is a mind-body exercise that shows a wide range of benefits in various medical conditions. The purpose of this study was to investigate the effect of Qigong exercise on NMS with a focus on sleep quality. Seventeen participants completed a 12-week intervention of Qigong (n = 8) or sham Qigong (n = 9). Disease severity, anxiety and depression levels, fatigue, cognition, quality of life, and other NMS of the par...
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
This cohort study of individuals with and without burning mouth syndrome uses data from the Korean National Health Insurance Service to examine the association between burning mouth syndrome and the risk of developing psychoneurological conditions among patients with burning mouth syndrome.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
In this issue of JAMA Otolaryngology –Head&Neck Surgery, J.-Y. Kim et al report a population-based study using the Korean National Health Insurance Service –National Sample Cohort database that collected data on a large nationwide cohort. The main aim of the study was to investigate the incidence of psychopathological (anxiety and depression) and neurological (dementia and Parkinson disease) conditions in patients with a clinical diagnosis of burning mouth syndrome (patient group) who were matched with individuals without burning mouth syndrome (comparison group). The hypothesis was that a shared neuropathi...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
CONCLUSIONS: In this sample of PD patients, there is no association between headache and PD. PMID: 32320054 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
This study was designed to assess the impact of nonmotor symptoms (NMSs) on sleep quality in early-stage PD patients with and without cognitive dysfunction.Materials and Methods: A sample of 389 early-stage PD patients (modified Hoehn and Yahr score ≤ 2.5, duration ≤ 5 years) was recruited for the present study. The Non-Motor Symptoms Questionnaire (NMS-Quest) was used to screen for global NMSs. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HAMD). PD motor symptoms were measured with the Unified PD Rating Scale (UPDRS), part III. The Montreal Cognitive Assessment (MoCA) was used to...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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