Basic fibroblast growth factor reduces the functional and structural damage in chronic kidney disease.

BASIC FIBROBLAST GROWTH FACTOR REDUCES THE FUNCTIONAL AND STRUCTURAL DAMAGE IN CHRONIC KIDNEY DISEASE. Am J Physiol Renal Physiol. 2013 Nov 27; Authors: Villanueva S, Contreras F, Tapia A, Carreño JE, Vergara C, Ewertz E, Cespedes C, Irarrazabal C, Sandoval M, Velarde V, Vio CP Abstract Chronic kidney disease (CKD) is characterized by loss of renal function. The pathological processes involved in the progression of this condition are already known, but the molecular mechanisms have not been completely explained. Recent reports have shown the intrinsic capacity of the kidney to undergo repair after acute injury through the re-expression of repairing proteins. Stimulation with basic Fibroblast Growth Factor (bFGF) could accelerate this process. However, it is not known whether bFGF can induce this phenomenon in kidney cells affected by CKD. Our aim was to study the evolution of renal damage in animals with CKD treated with bFGF, and to relate the amount of repairing proteins with renal damage progression. Male Sprague Dawley rats were subjected to 5/6 nephrectomy (NPX) and treated with bFGF (30 μg/kg, NPX+bFGF); a control NPX group was treated with saline (NPX+S). Animals were sacrificed 35 days after bFGF administration. Functional effects were assessed based on serum creatinine levels; morphological damage was assessed by the presence of macrophages (ED-1), interstitial α-smooth muscle actin (α-SMA) and interstitial collagen through Sirius...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research