Fennel as a cause of immediate hypersensitivity to toothpaste
Ingredients in toothpaste may cause allergic and irritant contact stomatitis (Table I). Flavourings are most commonly incriminated, as they are present in 95% of toothpastes.1 Less frequently, cinnamon, fluoride and Anethole (Anise camphor) have been suggested to cause local irritation.2,3 Pruritis and flexural dermatitis to toothpaste has been reported in a 50-year-old woman sensitized to stannous fluoride (SnF2) on patch testing.4
Authors: Calzavara-Pinton P, Belloni Fortina A, Bonamonte D, Marseglia GL, Miraglia Del Giudice M, Musarra A, Nettis E, Neri I, Patruno C, Stingeni L, Peris K, RADAR Group Abstract Atopic dermatitis (AD) is a chronic inflammatory disease with increasing global incidence, which has a multifactorial pathogenesis and a variable expressivity. Clinical features of AD are different in adults compared to children, but it is well recognized the substantial impact of the disease on patients' quality of life at any age. Indeed, little is known about AD in adolescence, a period of life generally associated with high psycholog...
The incidence of allergic diseases has increased over the last two decades.1 The study of the origins of allergy is an important topic, both to understand the mechanisms of allergy development and to produce interventions to treat or prevent allergic diseases. The term atopic march is used to describe the progression of allergic disease development, beginning with atopic dermatitis (AD) and progressing to food allergy (FA), asthma, and allergic rhinitis (AR). While it is necessary to focus on early childhood factors, the prenatal environment must also be considered.
CONCLUSIONS: AD incidence in our cohort was high and several risks factors were related to AD. PMID: 32402624 [PubMed - as supplied by publisher]
Food allergy (FA) and atopic dermatitis (AD) are more common among children born in fall, with a meta-analysis finding a significant odds ratio (OR) of 1.16 comparing fall to spring birth.2 However, studies have been performed in ethnically homogenous populations in Asia and Europe, with mixed results. To our knowledge, the association of AD with season of birth has not been replicated in the U.S. We used nationwide Medicaid claims data to examine the effect of season of birth on FA and AD, examining whether any effect continued throughout childhood and whether it differed by race.
PMID: 32389781 [PubMed - as supplied by publisher]
Although previous studies had reported an important role of interleukin 13 (IL13) and its genetic polymorphisms in atopic dermatitis (AD), many of these previous reports focused on the missense variant rs20541 (Gln144Arg) without fine mapping of the gene region.
Although previous studies have reported an important role of IL - 13 and its genetic polymorphisms in atopic dermatitis (AD), many of these prior reports focused on the missense variant rs20541 (Gln144Arg) without fine mapping of the gene region.
CONCLUSION: An additional IL-13 gene SNP, rs1295685, shows a strong linkage disequilibrium with rs20541, and its haplotypes are associated with AD and the total serum IgE levels. PMID: 32371243 [PubMed - as supplied by publisher]
Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes both on a macro and micro scale, which have led to reduced microbial exposure in early life and perturbation of the human microbiome composition. Increasing evidence shows that early life interactions between the human microbiome and the immune cells...