Abeta42 oligomers up-regulate the excitatory synapses by potentiating presynaptic release while impairing postsynaptic NMDA receptors.

In conclusion, Abeta42 up-regulates NMDA synaptic responses with a mechanism involving RyRs that occurs during the early stages of AD onset. This suggests that new selective modulators of RyRs may be useful for designing effective therapies to treat AD patients. This article is protected by copyright. All rights reserved.
PMID: 32246769 [PubMed - as supplied by publisher]

Source: The Journal of Physiology - April 3, 2020 Category: Physiology Authors: Marcantoni A, Cerullo MS, Buxeda P, Tomagra G, Giustetto M, Chiantia G, Carabelli V, Carbone E Tags: J Physiol Source Type: research