Current and Future Vistas in Bipolar Disorder

AbstractPurpose of ReviewThis paper aims to provide a succinct and narrative review of key developments in the diagnostic criteria, neurobiology, and treatment of bipolar disorder (BD).Recent FindingsDepressive symptoms/episodes and cognitive dysfunction are critical mediators of human capital, quality of life, and wellness in persons with BD. Significant advances in tolerability and incremental advances in efficacy exist with antimanic agents. Bipolar depression treatment options remain suboptimal with relatively few being metabolically neutral. In silico modeling and advanced computational methods provide promise to further illuminate the neurobiology of BD and identify novel disease modifying therapies.SummaryOptimal outcomes in BD depend on careful comprehensive assessment, timely accurate diagnosis, with attention to treating and preventing depressive symptoms, cognitive deficits, psychosocial impairment, comorbidity, and suicidality. Attention to wellness is underemphasized in BD and should be contemporaneous with symptom mitigation strategies.
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research