Safety of calcipotriene and betamethasone dipropionate foam for the treatment of psoriasis.
Safety of calcipotriene and betamethasone dipropionate foam for the treatment of psoriasis. Expert Opin Drug Saf. 2020 Apr 03;: Authors: Amat-Samaranch V, Puig L Abstract Introduction: Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated red and scaly plaques. Most patients have mild disease that is usually controlled with topical treatment. Calcipotriene 0.05% and betamethasone dipropionate 0.064% (Cal/BD) in aerosol foam (Enstilar®) is a novel formulation, which has shown promising results in terms of efficacy and safety.Areas covered: This review evaluates the safety profile of Cal/BD aerosol foam and also the key points regarding to its efficacy. A literature search was performed in PubMed on November 2019 from the start of records. Additional references were searched and retrieved manually.Expert opinion: Cal/BD aerosol foam has proved its efficacy, safety and tolerability in several clinical trials and real clinical practice. It has also demonstrated higher efficacy than the ointment and gel formulations of the fixed combination. It has a low incidence of adverse events; nasopharyngitis and site application pain were the most frequently reported. Moreover, it is devoid of changes in calcium homeostasis and hypothalamic-pituitary-adrenal axis. As a result of its unique formulation, it is easily spread, is rapidly absorbed, and has a rapid onset of action. These features upgrade patient's satisfaction and they...
In conclusion, we suggest that in the presence of intolerance or resistance to colchicine, interleukin (IL)-1 inhibition could suppress peritoneal inflammation and prevent MSTs. PMID: 32477360 [PubMed - in process]
CONCLUSION: Inpatient consultations is very useful to the patient and managing physician. Although a better knowledge in the identification of common ophthalmic conditions can help to reduce the number of inpatient consults from other medical specialties. PMID: 32476114 [PubMed - in process]
does everyone have emergency airway/equipment/meds for in clinic procedure room? i only do simple joint/nerve and some lumbar injections. rest goes to ASC. i did have one episode of contrast allergy last year which made me think i should at least have epi pen in clinic.. what are people doing and what kits/meds do you have?
llo A Abstract Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic membrane, and the primary cilium. The structure of PC2 is characterized by a highly ordered C-terminal tail with an EF-motif (calcium-binding domain) and a canonical coiled-coil domain (CCD; interaction domain), and its activity is regulated by interacting partners and post-translational modifications. Calcium mobilization into the cytosol by PC2 has been mainly associated with cell growth and differentiation, and therefore mutations or dysfunction of PC2 lead to renal and cardiac consequences. Inte...
Conclusions: Tear and conjunctival cytokines, including IL-1 β, IL-2, IL-6, and TNF-α, were correlated with sensory hypersensitivity status in the DESOS groups, suggesting they play an important role in the discordance of symptoms outweighing signs. PMID: 32476816 [PubMed - in process]
Publication date: Available online 2 June 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Susan Hanson, Ashley Hanson, Dominic Aldington
Conclusion: Of note, the investigated serum RNAs decrease the false discovery rate of AMI to 3.2%. PMID: 32476991 [PubMed]
Authors: Gorry C Abstract The days are long and arduous, with end-less patients to attend, often in a foreign language, always on foreign shores. Far from family and the familiar. Sleep is fi tful at best for health profession-als serving in emergency situations-when sickness obeys no clock and patients' pain haunts even the quiet moments. The crisis scenario varies: post-earthquake, hurricane or tsunami; amid a cholera or Ebola epidemic. The countries vary: Haiti, Pakistan, Guatemala, Mozambique, Sierra Leone. What does not vary is the answer to the calls for help and Cuban professionals' commitment to care for th...
CONCLUSIONS: Studies on measurement properties of questionnaires in dance are scarce. Weak/moderate associations were found between the OSTRCQ, SEFIP, and the VAS-pain questionnaires. Future high-quality research should investigate measurement properties of these questionnaires within dance populations. The results contribute by substantiating choices when developing a surveillance system. PMID: 32479586 [PubMed - in process]
CONCLUSION: Both dancers and athletes frequently perform within a culture that is pressured and promotes behavior that ignores pain and injury. It is recommended that coaches, educators, and healthcare workers understand the influence of cumulative trauma on risk for orthopedic injury and incorporate trauma-informed care. PMID: 32479584 [PubMed - in process]