CC Grand Rounds (1) Myelokathectic Immunodeficiency Disorders: Tales from the Clinic (2) Ulcerative Colitis: An Atypical Th2 Disorder Mediated by NKT Cells

Date: Wednesday, 01 21, 2015; Speaker: Philip M. Murphy, MD, Chief, Laboratory of Molecular Immunology, NIAID; Warren Strober, MD, Chief, Mucosal Immunity Section, Laboratory of Host Defenses, NIAID; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events

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Condition:   Ulcerative Colitis Intervention:   Diagnostic Test: Red Density Sponsors:   Universitaire Ziekenhuizen Leuven;   Sapporo Medical University;   Imelda GI Clinical Research Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Methylation analysis, namely of MSH6, may contribute to the classification of dysplastic lesions in IBD- to be further tested in prospective studies. PMID: 32456486 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
AbstractImmunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (TH17) cells and regulatory T  cells (Treg cells) is involved in ulcerative colitis (UC) pathogenesis. Dendritic cells (DCs) are able to induce T  cell differentiation. Paeoniflorin (PF) is a monoterpene glucoside that is commonly used for treatment of autoimmune disease. However, the immunological mechanism of PF involvement in UC treatment is unclear. The present study aimed to explore whether PF can restore the TH17/Treg balance by modulating DCs. The effects of PF on D...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractUlcerative colitis (UC) is a type of inflammatory bowel disease characterized by inflammation of the large intestine, rectal bleeding, and abdominal pain. It can be alleviated by certain bioactive compounds, including α-linolenic acid (ALA), which is a bioactive component in fermented black radish (Raphanus sativus L. var.niger). The aim of this study was to evaluate the anti-inflammatory effects of ALA in dextran sulfate sodium (DSS)-induced UC in mice. UC was induced in C57BL/6 mice by allowing them to freely drink water containing 2.5% DSS for 7  days, followed by oral administration of ALA (30 and 60...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
ConclusionsOverall outcomes and practice in this study are consistent with previously published studies on IPAA nationally and internationally. While acceptable, the opportunity from surgical centre collaboration outside of the National Cancer and Acute Surgery Strategies is to offer still better outcomes for our patients.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
The traditional Chinese medicine Shen-ling-bai-zhu-san (SLBZS) is described in “Tai Ping Hui Min He Ji Ju Fang.” SLBZS has been shown to be effective against many gastrointestinal diseases. The present study aimed to investigate the effect of SLBZS on experimental colitis in mice and to define the potential mechanisms. Our data suggest that compared to the model group, SLBZS treatment increases mouse body weight and colon length, decreases the DAI score, and improves colonic injury. SLBZS reduces the production of cytokines (IL-1β, IL-18, and TNF-α) in colon tissue and mouse colonic mucosal epithelia...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Toledo Mauriño JJ, Fonseca-Camarillo G, Furuzawa-Carballeda J, Barreto-Zuñiga R, Martínez Benítez B, Granados J, Yamamoto-Furusho JK Abstract Introduction: TRPVs are a group of receptors with a channel activity predominantly permeable to Ca2+. This subfamily is involved in the development of gastrointestinal diseases such as ulcerative colitis (UC). The aim of the study was to characterize the gene and protein expression of the TRPV subfamily in UC patients and controls. Methods: We determined by quantitative PCR the gene expression of TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6 i...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Conclusion: Lnc-ITSN1-2 correlates with increased disease risk, activity, and inflammatory cytokines of IBD, and promotes IBD CD4+ T cell activation, proliferation, and Th1/Th17 cell differentiation by serving as a competing endogenous RNA for IL-23R via sponging miR-125a.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Kinugasa H, Hiraoka S, Oka S, Hiroyuki O PMID: 32448840 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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