A rare case of synchronous ovarian tumors: clinical case report and literature review.
A rare case of synchronous ovarian tumors: clinical case report and literature review. Rom J Morphol Embryol. 2019;60(4):1365-1370 Authors: Roşu GA, Furău GO, Ionescu CA, Dimitriu MCT, Neacşu A, Ioan RG, Călin FD, Matei A, Bănacu M, Popescu I, Gheorghiu D, Neacşu I, Bacalbaşa N, Furău CG Abstract Epithelial ovarian carcinoma makes up 90-95% of all ovarian malignancies, taking into account also low-malignant-potential tumors. The Krukenberg tumor is a rare metastatic adenocarcinoma (ADK) in the ovary, representing 1-2% of ovarian tumors. Multiple primary malignant neoplasms may exist when more than one cancerous tumor is diagnosed in the same or a different organ. The incidence of multiple primary cancers among malignancies is between 2.4% to 8%. The aim of this paper is to report the case of a 47-year-old patient with two synchronous malignant tumors involving both ovaries, one diagnosed as primary papillary serous cystadenocarcinoma and the other one diagnosed as ovarian metastasis (Krukenberg tumor) of a synchronous colorectal ADK, and the complex diagnostic and therapeutic challenges that such a rare case poses. Histopathological (HP) examination and especially the immunohistochemical analysis had a determining role in differentiating between an ovarian primary tumor and a metastasis from a gastrointestinal tract cancer. The tumors examination for somatic mutations of Kirsten rat sarcoma viral oncogene homolog (KRAS) and neuroblastoma RAS viral...
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Qi Fu, Zhenhai Yu
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu, Ti Zhang
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Nagesh Kishan Panchal, E.P. Sabina
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Publication date: Available online 30 May 2020Source: Urology Case ReportsAuthor(s): Andrew Moe, Isaac Thyer, Rajalingam Sinniah, Dickon Hayne
This study is aimed at determining the prevalence of severe depression in Iranian women with breast...
Publication date: Available online 30 May 2020Source: European Journal of Surgical OncologyAuthor(s): R.H. Bhogal, P.H. Patel, S.L.F. Doran, S. Zar, J.M. Pollok, L.R. Jiao, W.H. Allum, M.A. Chaudry, S. Kumar
Publication date: Available online 29 May 2020Source: Respiratory InvestigationAuthor(s): Yoshiaki Kinoshita, Hiroshi Ishii, Yoshinobu Eishi, Keisuke Uchida, Masayo Yoshimura, Akinori Iwasaki, Masaki Fujita, Kazuki Nabeshima, Kentaro Watanabe
This study aimed to evaluate the effects of LLV on HCC development, mortality, and cirrhotic complications among patients according to their adherence to entecavir (ETV) treatment. Methods: We performed a retrospective observational analysis of data from 894 consecutive adult patients with treatment-naïve CHB undergoing ETV treatment. LLV was defined according to either persistent or intermittent episodes of
Conclusions: After sorafenib failure, the use of nivolumab may be associated with improved OS and better objective response rate as compared to using regorafenib. PMID: 32460459 [PubMed - as supplied by publisher]