Metastatic renal cell carcinoma to the earlobe 27 years after nephrectomy.

We present a case of a nodule on the earlobe of an elderly patient, without any known clinical history. Microscopic examination revealed a tumor with morphology reminiscent of metastatic clear cell renal cell carcinoma. The results of an extensive immunohistochemical (IHC) examination confirmed our initial diagnosis and further investigation of the patient's medical history revealed that a unilateral nephrectomy had been performed 27 years prior to the current tumor. We are reporting this case to emphasize the long interval between the primary tumor and its metastasis in an extremely unusual site, with a brief discussion on the ability of this particular neoplasm for extremely late metastasis to any site on the human body. Also, we are highlighting the extensive step-by-step IHC examination to confirm the diagnosis in routine pathology. PMID: 32239120 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

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Ascertaining the clinical benefit for lymph node dissection (LND) at the time of radical nephrectomy (RN) for renal cell carcinoma (RCC) has been challenging. At issue in determining the therapeutic or staging benefits of LND may be the quality of the lymph node dissection (number of lymph nodes harvested) or anatomic boundaries. Furthermore, prior studies have been limited by these issues and level of evidence. In this issue of Urology, Gershman et al. applied a validated observational analysis methodology with a large oncologic database to emulate 2 clinical trials in attempt to further examine the potential therapeutic ...
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Abstract BACKGROUND: Radical nephrectomy and thrombectomy is the standard surgical procedure for the treatment of renal cell carcinoma (RCC) with tumor thrombus (TT). But the estimation of intra-operative blood loss is only based on the surgeon's experience. Therefore, our study aimed to develop Peking University Third Hospital score (PKUTH score) for the prediction of intra-operative blood loss volume in radical nephrectomy and thrombectomy. METHODS: The clinical data of 153 cases of renal mass with renal vein (RV) or inferior vena cava tumor thrombus admitted to Department of Urology, Peking University Thir...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Abstract Pazopanib is an orally available multi-tyrosine kinase inhibitor and has been used to treat renal cell carcinoma (RCC). Here, we report the case of a patient with RCC with an increased prothrombin time- international normalized ratio (PT-INR) due to pazopanib therapy. In addition, we have reported the change in the blood levels of pazopanib. A 75-year-old man underwent a left nephrectomy for RCC. Four years later, his cancer recurred and pazopanib therapy was initiated. He was also taking warfarin for atrial fibrillation and his PT-INR was constant at approximately 2. His warfarin dose was reduced from 3....
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
An 80 year old male presented to the emergency department after an episode of gross hematuria four hours prior. Review of systems at the emergency department was positive for dysuria and chronic obstructive urinary symptoms while negative for fevers, chills, or flank pain. Of note, his past medical history includes atrial fibrillation on rivaroxaban anticoagulation, left bundle branch block, coronary artery disease (status post drug eluting stent placement to the left circumflex artery in 2003 and drug eluting stent placement to the left anterior descending artery in 2013), peripheral vascular disease (status post bilatera...
Source: Urology - Category: Urology & Nephrology Authors: Tags: Grand Rounds Source Type: research
CONCLUSIONS: To the best of our knowledge, this is the first case series study describing kidney tumors following HT. With the improving outcomes and life expectancy of HT patients, a better understanding of the factors that determine cancer risk is of the utmost importance and may have a major impact on the non-cardiac surveillance. PMID: 32378819 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Publication date: Available online 7 May 2020Source: European UrologyAuthor(s): Géraldine Pignot, Antoine Thiery-Vuillemin, Jochen Walz, Pierre Bigot, Karim Bensalah, Gwenaelle Gravis, Philippe Barthélémy
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSION: The laparoscopic NP in our center hasa MIC scope similar to international series, without havinga direct association with the RS. PMID: 32379064 [PubMed - as supplied by publisher]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Publication date: Available online 30 April 2020Source: European UrologyAuthor(s): Nirmish Singla, Vitaly Margulis
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 30 April 2020Source: European UrologyAuthor(s): Bimal Bhindi, Jeffrey Graham, J. Connor Wells, Ziad Bakouny, Frede Donskov, Anna Fraccon, Felice Pasini, Jae Lyun Lee, Naveen S. Basappa, Aaron Hansen, Christian K. Kollmannsberger, Ravindran Kanesvaran, Takeshi Yuasa, D. Scott Ernst, Sandy Srinivas, Brian I. Rini, Isaac Bowman, Sumanta K. Pal, Toni K. Choueiri, Daniel Y.C. Heng
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsThe current study constructed and validated an effective prognostic nomogram for patients with sRCC, which can be used to perform accurate predictions of the 0.5-, 1-, and 2-year possibilities of OS.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
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