2,4-Thiazolidinedione as precursor to the synthesis of compounds with antiglioma activities in C6 and GL261 cells.

CONCLUSION: The compounds were not cytotoxic in astrocyte culture, demonstrating selectivity for malignant cells. Changes in both rings are important for antiglioma activity in the cell lines tested. TZD 4CI had the best antiglioma activity.
PMID: 32242786 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - April 1, 2020 Category: Chemistry Authors: de Vasconcelos A, Boeira AJZ, Drawanz BB, Pedra NS, Bona NP, Stefanello FM, Cunico W Tags: Med Chem Source Type: research