Phospho-Proteomic Discovery of Novel EPO Signal Transducers Including TXNIP as a Mediator of EPO- Dependent Human Erythropoiesis

The production of erythroid progenitors requires signals provided by EPO and its JAK2- coupled receptor, EPOR3. rh-EPO and related EPOR agonists are also important therapeutics for the anemia of chronic kidney disease4, myelodysplastic syndrome5 and chemotherapy6. While EPO's actions have accordingly been intensely studied7,8, an advanced understanding of EPO/EPOR/JAK2 effects is important for several reasons. Clinically, and via poorly understood mechanisms, EPO also elicits hypertensive and thrombolytic side effects9.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Normal Hematopoiesis Source Type: research