Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation

Publication date: Available online 4 April 2020Source: Journal of EthnopharmacologyAuthor(s): Ying-Nan Jiang, Yong-Zhi Guo, Dan-Hua Lu, Ming-Hai Pan, Hai-Zhi Liu, Gen-Long Jiao, Wei Bi, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He, Xin-Sheng Yao
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Conclusion: The study landscape of this review highlights the scarcity of, poor reporting on, and unclear methodologic quality of research on SBS strain patterns in disease and health. It is still unclear whether and to what extent specific SBS strain patterns occur in impaired health states compared with healthy controls. Future studies should seek to improve study methods and reporting and minimize the risk of bias. PMID: 32451540 [PubMed - in process]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Authors: Gomez-Inhiesto E, Acaiturri-Ayesta MT, Ustarroz-Aguirre I, Camahuali D, Urtaran-Laresgoiti M, Basabe-Aldecoa M, Nuño-Solinís R, Urizar E Abstract Parkinson's disease is one of the main reasons for neurological consultation in Spain. Due to the nature of the disease, it impacts patients, families, and caregivers. Parkinson's disease is a degenerative disease with no cure, although second-line therapies have recently improved the quality of life of patients in advanced stages. The aim of this study was to analyse the costs of the following therapies: deep brain stimulation (DBS), continuous duo...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
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Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Departments Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Jerrold L Vitek, Roshini Jain, Lilly Chen, Alexander I Tröster, Lauren E Schrock, Paul A House, Monique L Giroux, Adam O Hebb, Sierra M Farris, Donald M Whiting, Timothy A Leichliter, Jill L Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A Karl, Mustafa S Siddiqui, Stephen B Tatter, Ihtsham ul Haq
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Günther Deuschl, Paul Krack
Source: The Lancet Neurology - Category: Neurology Source Type: research
AbstractObjectiveTimed neuropsychological tests do not take into account physical impairment during scoring procedures. Dysarthria and upper limb impairment can be easily measured with the PATA rate test (PRT) and the nine-hole pegboard test (9HPT). We recently validated a normalization method for timed neuropsychological tests using the PRT and 9HPT (p9NORM). We now validate the p9NORM in Parkinson ’s disease (Yarnall et al. Neurology 82(4):308–316;2014) and multiple system atrophy (MSA).MethodsWe enrolled twenty-six patients with PD, eighteen patients with MSA, and fifteen healthy controls (HC). p9NORM was ap...
Source: Neurological Sciences - Category: Neurology Source Type: research
Mucus is integral to gut health and its properties may be affected in neurological disease. Mucus comprises a hydrated network of polymers including glycosylated mucin proteins. We propose that factors that influence the nervous system may also affect the volume, viscosity, porosity of mucus composition and subsequently, gastrointestinal (GI) microbial populations. The gut has its own intrinsic neuronal network, the enteric nervous system, which extends the length of the GI tract and innervates the mucosal epithelium. The ENS regulates gut function including mucus secretion and renewal. Both dysbiosis and gut dysfunction a...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, we employed a model system for PD of cultured primary mesencephalic cells and used the pesticide rotenone to model dopaminergic cell damage. We examined neuroprotective effects of the Rho kinase inhibitor Fasudil and the short chain fatty acid (SCFA) propionic acid on primary neurons in cell morphological assays, cell survival, gene and protein expression. Fasudil application resulted in significantly enhanced neuritic outgrowth and increased cell survival of dopaminergic cells. The application of propionic acid primarily promoted cell survival of dopaminergic cells against rotenone toxicity and increased ne...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusions: The consistent increase in MRI measures of iron content in PD across the literature using R2*, SWI, or QSM techniques confirmed that these measurements provided reliable markers of iron content in PD. Several of these measurements correlated with the severity of motor symptoms. Lastly, QSM appeared more robust and reproducible than R2* and more suited to multicenter studies.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Objective: To evaluate the extent to which cancer, a biological opposite to neurodegenerative disorders, may affect the onset and progression of Parkinson's disease (PD).Methods: A nested case-control design in consecutive PD patients with (cases) vs. without (controls) cancer was used to compare time to clinical diagnosis and time to Hoehn &Yahr (H&Y) staging score ≥ 3 as a measure of progression. Further, we compared PD onset and progression between cases with cancer diagnosis before (cancer before PD group) and after (cancer after PD group) PD onset. Independent variables were age at PD onset, motor subscale of t...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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