Influence of long-standing pulmonary arterial hypertension and its severity on pulmonary artery aneurysm development

AbstractPulmonary artery aneurysm (PAA) is a common finding in patients with long-term pulmonary arterial hypertension (PAH). The influence of PAH severity in the development of PAA remains unclear. We sought to determine whether PAA development is related to PAH severity and whether treatment optimization based on risk profile estimation is effective to stop pulmonary artery (PA) enlargement. This is a retrospective study of 125 PAH patients who underwent an imaging test (computed tomography or magnetic resonance) combined with a right heart catheterization within a six-month period. A multivariate analysis was performed to identify independent risk factors for PAA. Patients who underwent an additional imaging-test and RHC during follow-up were analyzed to evaluate changes on PA dimensions. PAA was diagnosed in 42 (34%) patients. PAA was more frequent in patients with congenital heart disease and toxic oil syndrome. PAH time-course showed to be an independent risk factor for PAA (HR 1.051, 95% CI 1.013 –1.091,p = 0.008) whereas PAH severity did not. Twenty-six patients underwent a follow-up imaging-test and catheterization. After treatment optimization, a non-significant reduction of mean PA pressure was observed (58.5 mmHg [43.5–70.8] vs. 55.5 mmHg [47.5–66.3],p = 0.115) and a higher proportion of patients achieved a low-risk profile (19% vs. 35%,p = 0.157). However, the PA diameter significantly increase...
Source: Heart and Vessels - Category: Cardiology Source Type: research

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HIGH BLOOD PRESSURE may seem harmless but the condition can be a precursor to heart disease so it is important to keep it in check. Nuts have been shown to have a moderating effect on blood pressure and one nut comes out on top.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractBackgroundThe purpose of this study was to measure trends in the use of tranexamic acid (TXA) during delivery in the United States and to evaluate demographic data and morbidity outcomes among these patients.MethodsThis retrospective cohort study includes data from 19 hospitals in the Universal Health Services network. We compared rates of TXA use between January 2015 and June 2019 across geographic sectors. We also evaluated associations of demographic variables and perinatal outcomes of women who received TXA.Results209 cases of TXA use were found from analysis of 101,564 deliveries. TXA use increased over time a...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
ConclusionAs clinicians, it can be challenging to provide our patients with accurate information on the risk of PPM implantation relative to their operation. A unit-specific data may be a more accurate method of informing our patients on this risk.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Authors: Lehto HR, Pietilä A, Niiranen TJ, Lommi J, Salomaa V Abstract Aims: To compare diabetic patients with coronary heart disease (CHD) needing revascularization to corresponding non-diabetic patients in terms of revascularization methods, comorbidities and urgency of procedure. We also examined the impact of patient characteristics and comorbidities on the revascularization method.Methods: We identified all diabetic (n = 33,018) and non-diabetic (n = 106,224) patients with first-ever, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) from electr...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
WEDNESDAY, May 20, 2020 -- Middle-aged men and women who develop high blood pressure while performing even moderate exercise may be at higher risk for heart disease, a new study suggests. " The way our blood pressure changes during and after...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 (COVID-19). SARS-CoV-2 causes viral pneumonia with additional extrapulmonary manifestations and major complications, including acute myocardial injury, arrhythmia, and shock mainly in elderly patients. Furthermore, patients with existing cardiovascular comorbidities, such as hypertension and coronary heart disease, have a worse clinical outcome following contraction of the viral illness. A striking feature of COVID-19 pandemics is the hig...
Source: AGE - Category: Geriatrics Source Type: research
By Emma Young We all know that too little sleep is bad for us. Matthew Walker, a UC Berkeley sleep scientist and author of the best-selling Why We Sleep, has gone so far as to declare: “The shorter you sleep, the shorter your life.” However, some researchers fear that our concerns about not getting enough sleep are becoming overblown — and that, ironically, they could be making the problem worse. In this feature, we take a look at evidence that “too little” sleep isn’t always the disaster that it’s held up to be. It’s not always about a lack of sleep You’ll be fami...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Feature Sleep and dreaming Source Type: blogs
ConclusionUnfortunately, there is considerable inconsistency among the databases searched, such that a clinician ’s discretion and clinical experience remain invaluable tools for the management of patients with comorbidities present in psychiatric and cardiac disorders. The possibility of an interaction should be considered. With a multidisciplinary approach, particularly involving a pharmacist, the prescrib er should be alerted to the possibility of an interaction. MDD and AD pharmacologic treatment in cardiac patients could be implemented safely both by cardiologists and psychiatrists.Trial RegistrationPROSPERO Sys...
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
ConclusionOur data suggest that cardiac biomarkers play an important role in the detection of cancer therapy-induced cardiotoxicity. Larger systematic assessment in prospective cohorts is mandatory.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract Studies seldom combine biological, behavioral and psychological factors to estimate coronary atherosclerotic heart disease (CHD) risk. Here, we evaluated the associations between these factors and CHD to develop a predictive nomogram to identify those at high risk of CHD. This case-control study included 4392 participants (1578 CHD cases and 2814 controls) in southeast China. Thirty-three biological, behavioral and psychological variables were evaluated. Following multivariate logistic regression analysis, which revealed eight risk factors associated with CHD, a predictive nomogram was developed based on ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
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