Total Syntheses and Cytotoxic Evaluations of Cryptolactones A1, A2, B1, B2, and Their Derivatives.

Total Syntheses and Cytotoxic Evaluations of Cryptolactones A1, A2, B1, B2, and Their Derivatives.
Chem Pharm Bull (Tokyo). 2020;68(4):380-383
Authors: Inai M, Oguri Y, Horikawa M, Kaku H, Suzuki S, Kitamura K, Tsunoda T
Abstract
The cryptolactones A1, A2, B1, and B2 isolated from a Cryptomyzus sp. aphid were synthesized via the Mukaiyama aldol reaction and olefin metathesis. Their antipodes and derivatives were also synthesized by the same strategy to investigate structure-activity relationships. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells with IC50 values of 2.1-42 µM.
PMID: 32238655 [PubMed - in process]

Source: Chemical and Pharmaceutical Bulletin - April 4, 2020 Category: Drugs & Pharmacology Authors: Inai M, Oguri Y, Horikawa M, Kaku H, Suzuki S, Kitamura K, Tsunoda T Tags: Chem Pharm Bull (Tokyo) Source Type: research