The association of balance, fear of falling, and daily activities with drug phases and severity of disease in patients with Parkinson - Mehdizadeh M, Martinez-Martin P, Habibi SA, Nikbakht N, Alvandi F, Bazipoor P, Panahi A, Taghizadeh G.

INTRODUCTION: In the elderly, functional balance, fear of falling, and independence in daily living activities are interrelated; however, this relationship may change under the influence of drug phase and the severity of disease in individuals with idiopat...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Departments Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Jerrold L Vitek, Roshini Jain, Lilly Chen, Alexander I Tröster, Lauren E Schrock, Paul A House, Monique L Giroux, Adam O Hebb, Sierra M Farris, Donald M Whiting, Timothy A Leichliter, Jill L Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A Karl, Mustafa S Siddiqui, Stephen B Tatter, Ihtsham ul Haq
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Günther Deuschl, Paul Krack
Source: The Lancet Neurology - Category: Neurology Source Type: research
AbstractObjectiveTimed neuropsychological tests do not take into account physical impairment during scoring procedures. Dysarthria and upper limb impairment can be easily measured with the PATA rate test (PRT) and the nine-hole pegboard test (9HPT). We recently validated a normalization method for timed neuropsychological tests using the PRT and 9HPT (p9NORM). We now validate the p9NORM in Parkinson ’s disease (Yarnall et al. Neurology 82(4):308–316;2014) and multiple system atrophy (MSA).MethodsWe enrolled twenty-six patients with PD, eighteen patients with MSA, and fifteen healthy controls (HC). p9NORM was ap...
Source: Neurological Sciences - Category: Neurology Source Type: research
In this study, we employed a model system for PD of cultured primary mesencephalic cells and used the pesticide rotenone to model dopaminergic cell damage. We examined neuroprotective effects of the Rho kinase inhibitor Fasudil and the short chain fatty acid (SCFA) propionic acid on primary neurons in cell morphological assays, cell survival, gene and protein expression. Fasudil application resulted in significantly enhanced neuritic outgrowth and increased cell survival of dopaminergic cells. The application of propionic acid primarily promoted cell survival of dopaminergic cells against rotenone toxicity and increased ne...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusions: The consistent increase in MRI measures of iron content in PD across the literature using R2*, SWI, or QSM techniques confirmed that these measurements provided reliable markers of iron content in PD. Several of these measurements correlated with the severity of motor symptoms. Lastly, QSM appeared more robust and reproducible than R2* and more suited to multicenter studies.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Objective: To evaluate the extent to which cancer, a biological opposite to neurodegenerative disorders, may affect the onset and progression of Parkinson's disease (PD).Methods: A nested case-control design in consecutive PD patients with (cases) vs. without (controls) cancer was used to compare time to clinical diagnosis and time to Hoehn &Yahr (H&Y) staging score ≥ 3 as a measure of progression. Further, we compared PD onset and progression between cases with cancer diagnosis before (cancer before PD group) and after (cancer after PD group) PD onset. Independent variables were age at PD onset, motor subscale of t...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Negri M, Gorgora M, Nasser JA, Salles JI, Teixeira S, Arias-Carrión O, Junqueira J, Nicoliche E, Velasques B, Cagy M, Budde H, Basile LF, Orsini M, Friede R, Bastos VH, Ribeiro P Abstract Chronic deep brain stimulation (CDBS) is a surgical treatment that reduces the cardinal signs of Parkinson's disease (PD). Although CDBS has been in use for a long time, very little has been reported on its supposed effects on cognition, particularly in relation to implants in the subthalamic nucleus. The results of the rare studies that do exist are controversial, and in many cases the studies have several design ...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
The objective of this psychometric study was to validate the Italian version of the BI in a population of patients with Parkinson's disease (PD). The study was conducted at three neurological and rehabilitation centres in Rome, Italy. The BI was administered to outpatients with PD. The reliability of the scale was assessed using Cronbach's alpha for internal consistency; the intra-class correlation coefficient (ICC) was used to measure its intra- and inter-rater reliability. Pearson's correlation coefficient was calculated to evaluate its validity, comparing it with the Parkinson's disease Questionnaire (PDQ-39), the Itali...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
Determination of atomoxetine or escitalopram in human plasma by HPLC: Applications in neuroscience research studies
. Int J Clin Pharmacol Ther. 2020 May 25;: Authors: Teichert J, Rowe JB, Ersche KD, Skandali N, Sacher J, Aigner A, Regenthal R Abstract BACKGROUND: Atomoxetine and escitalopram are potent and selective drugs approved for noradrenergic or serotonergic modulation of neuronal networks in attention-deficit hyperactivity disorder (ADHD) or depression, respectively. High-performance liquid chromatography (HPLC) methods still play an important role in the therapeutic drug monitoring (TDM) of ...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
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